Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | PDE2A | O00408 | 1/20 | 0.58 |
| ▸ | GRM5 | P41594 | 5/20 | 0.54 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.54 |
| ▸ | VNN1 | O95497 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5909199 | 1.00 | ALDH1A1 (0.64) | ALDH1A1KMT2ALMNAMEN1PDE2A | |
| SCHEMBL14731432 | 0.86 | ALDH1A1 (0.61) | ALDH1A1KMT2ALMNAMEN1PDE2A | |
| SCHEMBL5909223 | 0.84 | ALDH1A1 (0.72) | ALDH1A1KMT2ALMNAMEN1PDE2A | |
| SCHEMBL5909331 | 0.84 | ALDH1A1 (0.72) | ALDH1A1KMT2ALMNAMEN1PDE2A | |
| SCHEMBL5909361 | 0.84 | ALDH1A1 (0.72) | ALDH1A1KMT2ALMNAMEN1PDE2A | |
| SCHEMBL5909258 | 0.84 | GRM5 (0.54) | ALDH1A1KMT2ALMNAMEN1PDE2A | |
| SCHEMBL20687922 | 0.84 | GRM5 (0.67) | ALDH1A1KMT2ALMNAMEN1PDE2A | |
| SCHEMBL5909240 | 0.84 | GRM5 (0.71) | ALDH1A1KMT2ALMNAMEN1GRM5 | |
| SCHEMBL3387338 | 0.83 | SCN9A (0.52) | ALDH1A1GRM5GRM3VNN1 | |
| SCHEMBL8257885 | 0.83 | SCN9A (0.52) | ALDH1A1GRM5GRM3VNN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1494672-A1 | AMINOCARBONYL SUBSTITUTED PYRIDINES, PYRIDAZINES, PYRIMIDINES, PYRAZINES AND TRIAZINES HAVING ANTIANGIOGENIC ACTIVITY | Abbott Laboratories (US) | 2005-01-12 | — | — | EP | disclosed |
| WO-2003086398-A1 | AMINOCARBONYL SUBSTITUTED PYRIDINES, PYRIDAZINES, PYRIMIDINES, PYRAZINES AND TRIAZINES HAVING ANTIANGIOGENIC ACTIVITY | ABBOTT LABORATORIES (US) | 2003-10-23 | — | — | WO | disclosed |