Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyridine SCHEMBL28412077 | 0.97 | TDP1 (0.50) | TSHRNAPRTTDP1MEN1KMT2A | |
| Pyridine SCHEMBL27835773 | 0.81 | TSHR (0.50) | TSHRNAPRTTDP1 | |
| Benzene SCHEMBL11376367 | 0.80 | ALDH1A1 (0.30) | TDP1 | |
| Pyridine SCHEMBL28445938 | 0.78 | NAPRT (0.53) | TSHRNAPRTTDP1MEN1KMT2A | |
| Pyridine SCHEMBL27866726 | 0.77 | NAPRT (0.60) | TSHRNAPRTTDP1MEN1KMT2A | |
| Pyridine SCHEMBL5969174 | 0.77 | — | — | |
| Pyridine SCHEMBL571033 | 0.77 | — | — | |
| Pyridine SCHEMBL27994606 | 0.77 | NAPRT (0.60) | TSHRNAPRTTDP1MEN1KMT2A | |
| Benzene SCHEMBL28230783 | 0.77 | NAPRT (0.60) | TSHRNAPRTTDP1MEN1KMT2A | |
| Pyridine SCHEMBL15309118 | 0.76 | NAPRT (0.82) | TSHRNAPRTTDP1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0988285-B1 | PRODRUG FORMS OF RIBONUCLEOTIDE REDUCTASE INHIBITORS 3-AP AND 3-AMP | VION PHARMACEUTICALS INC (US) | 2005-11-09 | — | — | EP | disclosed |
| EP-0988285-A4 | PRODRUG FORMS OF RIBONUCLEOTIDE REDUCTASE INHIBITORS 3-AP AND 3-AMP | VION PHARMACEUTICALS INC (US) | 2000-08-16 | — | — | EP | disclosed |
| EP-0988285-A1 | PRODRUG FORMS OF RIBONUCLEOTIDE REDUCTASE INHIBITORS 3-AP AND 3-AMP | Vion Pharmaceuticals, Inc. (US) | 2000-03-29 | — | — | EP | disclosed |
| WO-1998051669-A1 | PRODRUG FORMS OF RIBONUCLEOTIDE REDUCTASE INHIBITORS 3-AP AND 3-AMP | VION PHARMACEUTICALS, INC. (US) | 1998-11-19 | — | — | WO | disclosed |
| US-5767134-A | Prodrug forms of ribonucleotide reductase inhibitors 3-AP and 3-AMP | VION PHARMACEUTICALS, INC. (US) | 1998-06-16 | — | — | US | disclosed |