Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 5/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.45 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.40 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6263224 | 0.89 | GAA (0.50) | HCRTR1GRM5GRM1GAAHPGD | |
| SCHEMBL6261879 | 0.84 | HCRTR2 (0.46) | HCRTR1GRM5GRM1GAAHPGD | |
| SCHEMBL7513166 | 0.80 | GAA (0.49) | HCRTR1GRM5GRM1GAAHPGD | |
| SCHEMBL6305666 | 0.79 | HCRTR2 (0.44) | HCRTR1GRM5GRM1GAAHPGD | |
| SCHEMBL7513161 | 0.78 | KMT2A (0.47) | HCRTR1GRM5GRM1GAAHPGD | |
| SCHEMBL7456545 | 0.76 | HPGD (0.55) | GRM5GRM1GAAHPGDPDE10A | |
| SCHEMBL22054767 | 0.76 | KMT2A (0.59) | GAAHPGDMEN1TSHRKMT2A | |
| SCHEMBL5909267 | 0.76 | KMT2A (0.53) | HCRTR1GAAHPGDMEN1TSHR | |
| SCHEMBL15064844 | 0.75 | HCRTR1 (0.58) | HCRTR1GRM5GRM1GAAHPGD | |
| SCHEMBL12754315 | 0.75 | HSD11B1 (0.51) | HCRTR1GRM5GAAHPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1494672-A1 | AMINOCARBONYL SUBSTITUTED PYRIDINES, PYRIDAZINES, PYRIMIDINES, PYRAZINES AND TRIAZINES HAVING ANTIANGIOGENIC ACTIVITY | Abbott Laboratories (US) | 2005-01-12 | — | — | EP | disclosed |
| WO-2003086398-A1 | AMINOCARBONYL SUBSTITUTED PYRIDINES, PYRIDAZINES, PYRIMIDINES, PYRAZINES AND TRIAZINES HAVING ANTIANGIOGENIC ACTIVITY | ABBOTT LABORATORIES (US) | 2003-10-23 | — | — | WO | disclosed |