Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.49 |
| ▸ | ATG4B | Q9Y4P1 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | CFD | P00746 | 1/20 | 0.45 |
| ▸ | C1S | P09871 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4810433 | 0.78 | KMT2A (0.68) | LMNAKMT2AALOX15SMN1; SMN2PLA2G1B | |
| SCHEMBL413254 | 0.78 | LMNA (0.81) | LMNAKMT2AALOX15MAPTALDH1A1 | |
| SCHEMBL6265173 | 0.77 | HPGD (0.54) | LMNAKMT2AALOX15SMN1; SMN2PLA2G1B | |
| Iodide SCHEMBL30758523 | 0.77 | KMT2A (0.66) | LMNAKMT2AALOX15SMN1; SMN2PLA2G1B | |
| SCHEMBL15200218 | 0.77 | KMT2A (0.61) | LMNAKMT2AALOX15SMN1; SMN2PLA2G1B | |
| SCHEMBL6624505 | 0.77 | KMT2A (0.55) | LMNAKMT2AALOX15SMN1; SMN2PLA2G1B | |
| SCHEMBL6264975 | 0.76 | KMT2A (0.50) | LMNAKMT2AALOX15SMN1; SMN2PLA2G1B | |
| SCHEMBL4679397 | 0.74 | LMNA (0.70) | LMNAALOX15 | |
| SCHEMBL14799462 | 0.74 | NPC1 (0.71) | LMNASMN1; SMN2TDP1MAPTHPGD | |
| SCHEMBL12768208 | 0.73 | PLA2G1B (0.64) | LMNAKMT2AALOX15SMN1; SMN2PLA2G1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005081954-A2 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE 1B | WYETH (US) | 2005-09-09 | — | — | WO | disclosed |