Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 20/20 | 0.82 |
| ▸ | MMP13 | P45452 | 15/20 | 0.82 |
| ▸ | MMP1 | P03956 | 10/20 | 0.82 |
| ▸ | MMP9 | P14780 | 10/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3946208 | 0.99 | ADAM17 (0.81) | ADAM17MMP13MMP1MMP9 | |
| Hydrochloric Acid SCHEMBL3944267 | 0.91 | ADAM17 (0.85) | ADAM17MMP13MMP1MMP9 | |
| SCHEMBL4029689 | 0.90 | ADAM17 (1.00) | ADAM17MMP13MMP1MMP9 | |
| SCHEMBL4023432 | 0.90 | ADAM17 (1.00) | ADAM17MMP13MMP1MMP9 | |
| SCHEMBL6265558 | 0.90 | ADAM17 (1.00) | ADAM17MMP13MMP1MMP9 | |
| SCHEMBL6265272 | 0.90 | ADAM17 (1.00) | ADAM17MMP13MMP1MMP9 | |
| SCHEMBL4029908 | 0.89 | ADAM17 (0.85) | ADAM17MMP13MMP1MMP9 | |
| SCHEMBL6756175 | 0.89 | ADAM17 (0.83) | ADAM17MMP13MMP1MMP9 | |
| SCHEMBL6269089 | 0.87 | ADAM17 (1.00) | ADAM17MMP13MMP1MMP9 | |
| SCHEMBL3939692 | 0.85 | ADAM17 (0.80) | ADAM17MMP13MMP1MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147085-B1 | ALKYNYL CONTAINING HYDROXAMIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MATRIX METALLOPROTEINASE (MMP) INHIBITORS / TNF-ALPHA CONVERTING ENZYME (TACE) INHIBITORS | WYETH CORP (US) | 2005-11-16 | — | — | EP | claimed |