Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 9/20 | 0.48 |
| ▸ | SGMS2 | Q8NHU3 | 2/20 | 0.40 |
| ▸ | ACP1 | P24666 | 1/20 | 0.40 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.40 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.40 |
| ▸ | SSU72 | Q9NP77 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6269800 | 1.00 | LRRK2 (0.48) | LRRK2SGMS2ACP1PTPN12PTPN13 | |
| SCHEMBL6267508 | 0.91 | FOLH1 (0.39) | LRRK2ACP1PTPN12PTPN13SSU72 | |
| SCHEMBL6267511 | 0.91 | FOLH1 (0.39) | LRRK2ACP1PTPN12PTPN13SSU72 | |
| SCHEMBL6267521 | 0.91 | AKR1C3 (0.40) | LRRK2AKR1C3KMT2A | |
| SCHEMBL6267524 | 0.91 | AKR1C3 (0.40) | LRRK2AKR1C3KMT2A | |
| SCHEMBL6273369 | 0.91 | LRRK2 (0.39) | LRRK2AKR1C3KMT2A | |
| SCHEMBL6272446 | 0.91 | KCNH2 (0.40) | LRRK2 | |
| SCHEMBL6272451 | 0.91 | KCNH2 (0.40) | LRRK2 | |
| SCHEMBL6273370 | 0.91 | LRRK2 (0.39) | LRRK2AKR1C3KMT2A | |
| SCHEMBL6267977 | 0.90 | PTPN2 (0.40) | ACP1PTPN12PTPN13SSU72MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005110981-A1 | AMINOALCOHOL DERIVATIVES | ASTELLAS PHARMA INC. (JP) | 2005-11-24 | — | — | WO | disclosed |