Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 17/20 | 0.78 |
| ▸ | MMP13 | P45452 | 12/20 | 0.58 |
| ▸ | MMP1 | P03956 | 10/20 | 0.58 |
| ▸ | MMP9 | P14780 | 9/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 2/20 | 0.44 |
| ▸ | MMP14 | P50281 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6262885 | 0.88 | ADAM17 (1.00) | ADAM17MMP13MMP1MMP9 | |
| SCHEMBL6268610 | 0.88 | ADAM17 (0.77) | ADAM17MMP13MMP1MMP9MMP2 | |
| SCHEMBL6268734 | 0.87 | ADAM17 (0.76) | ADAM17MMP13MMP1MMP9MMP2 | |
| SCHEMBL6261871 | 0.85 | ADAM17 (0.86) | ADAM17MMP13MMP1MMP9KDM4E | |
| SCHEMBL6267659 | 0.85 | ADAM17 (0.75) | ADAM17MMP13MMP1MMP9 | |
| SCHEMBL6268614 | 0.84 | ADAM17 (0.78) | ADAM17MMP13MMP1MMP9 | |
| Hydroxyamine SCHEMBL4033564 | 0.84 | ADAM17 (0.83) | ADAM17MMP13MMP1MMP9KDM4E | |
| SCHEMBL4033569 | 0.83 | ADAM17 (0.82) | ADAM17MMP13MMP1MMP9KDM4E | |
| SCHEMBL6270058 | 0.82 | ADAM17 (0.57) | ADAM17MMP13MMP1MMP9MMP2 | |
| SCHEMBL6265887 | 0.82 | ADAM17 (0.80) | ADAM17MMP13MMP1MMP9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147085-B1 | ALKYNYL CONTAINING HYDROXAMIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MATRIX METALLOPROTEINASE (MMP) INHIBITORS / TNF-ALPHA CONVERTING ENZYME (TACE) INHIBITORS | WYETH CORP (US) | 2005-11-16 | — | — | EP | claimed |