SCHEMBL6270213

SCHEMBL6270213

Fc1ccc(Nc2nc[nH]c3ncc(-c4ccccc4)c2-3)cc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FGFR1 P11362 2/20 0.44
ABCG2 Q9UNQ0 1/20 0.43
MKNK1 Q9BUB5 1/20 0.42
CYP1A2 P05177 6/20 0.40
CYP3A4 P08684 6/20 0.40
CYP2C19 P33261 6/20 0.40
MAPK1 P28482 4/20 0.40
MAPT P10636 3/20 0.40
HPGD P15428 3/20 0.40
TDP1 Q9NUW8 3/20 0.40
HSD17B10 Q99714 3/20 0.40
TSHR P16473 2/20 0.40
KDM4E B2RXH2 1/20 0.40
ADORA1 P30542 1/20 0.40
CYP2D6 P10635 5/20 0.39
ALDH1A1 P00352 3/20 0.39
MEN1 O00255 2/20 0.39
KMT2A Q03164 2/20 0.39
LMNA P02545 2/20 0.38
PTGS2 P35354 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6684324 0.93 MKNK1 (0.45) FGFR1MKNK1CYP1A2CYP3A4CYP2C19
SCHEMBL6677800 0.91 MAPT (0.46) CYP1A2CYP3A4CYP2C19MAPK1MAPT
SCHEMBL6240412 0.87 ABCG2 (0.41) FGFR1ABCG2CYP3A4MAPTHPGD
SCHEMBL6683647 0.87 PDE5A (0.41) ABCG2MKNK1MAPTHPGDHSD17B10
SCHEMBL6236885 0.83 CDC7 (0.55) MAPK1MAPTHPGDTDP1KDM4E
SCHEMBL6876454 0.82 PTK2 (0.40) FGFR1MAPTADORA1LMNA
SCHEMBL6235443 0.76 TP53 (0.41) MAPK1MAPTHPGDHSD17B10TSHR
SCHEMBL6237608 0.73 CDC7 (0.35) FGFR1CYP3A4MAPTKDM4EADORA1
SCHEMBL9986916 0.73 TNNI3K (0.59)
SCHEMBL28549594 0.70 CYP3A4 (0.41) CYP3A4MAPTKDM4EADORA1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1052264-B1 Process for the synthesis of nucleoside analogs PFIZER PROD INC (US) 2005-03-23 EP claimed
US-6271370-B1 REACTING 2',3'-O-ALKYLIDENE .BETA.-FURANOSYL HALIDE COMPOUND WITH HETEROCYCLE HAVING RING NITROGEN CAPABLE OF FORMING COVALENT BOND WITH ANOMERIC CARBON OF FURANOSE OR FURANOSE ANALOG IN DIMETHYL SULFOXIDE IN PRESENCE OF STRONG BASE PFIZER INC 2001-08-07 US claimed
EP-1052264-A2 Process for the synthesis of nucleoside analogs Pfizer Products Inc. (US) 2000-11-15 EP claimed
EP-1052264-B1 Process for the synthesis of nucleoside analogs PFIZER PROD INC (US) 2005-03-23 EP disclosed
EP-0832092-B1 ORALLY ACTIVE ADENOSINE KINASE INHIBITORS METABASIS THERAPEUTICS INC (US) 2004-11-17 EP disclosed
EP-0832091-B1 C-4' MODIFIED ADENOSINE KINASE INHIBITORS GENSIA SICOR INC (US) 2004-01-14 EP disclosed
US-6271370-B1 REACTING 2',3'-O-ALKYLIDENE .BETA.-FURANOSYL HALIDE COMPOUND WITH HETEROCYCLE HAVING RING NITROGEN CAPABLE OF FORMING COVALENT BOND WITH ANOMERIC CARBON OF FURANOSE OR FURANOSE ANALOG IN DIMETHYL SULFOXIDE IN PRESENCE OF STRONG BASE PFIZER INC 2001-08-07 US disclosed
EP-1052264-A2 Process for the synthesis of nucleoside analogs Pfizer Products Inc. (US) 2000-11-15 EP disclosed
EP-0832092-A1 ORALLY ACTIVE ADENOSINE KINASE INHIBITORS GENSIA, INC. (US) 1998-04-01 EP disclosed
EP-0832091-A1 C-4' MODIFIED ADENOSINE KINASE INHIBITORS GENSIA, INC. (US) 1998-04-01 EP disclosed
WO-1996040705-A1 C-4' MODIFIED ADENOSINE KINASE INHIBITORS GENSIA SICOR (US) 1996-12-19 WO disclosed
WO-1996040706-A1 ORALLY ACTIVE ADENOSINE KINASE INHIBITORS GENSIA-SICOR (US) 1996-12-19 WO disclosed