Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 2/20 | 0.55 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.55 |
| ▸ | CDK1 | P06493 | 5/20 | 0.46 |
| ▸ | KDR | P35968 | 5/20 | 0.46 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.39 |
| ▸ | STAT6 | P42226 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6677800 | 0.86 | MAPT (0.46) | CDC7ALKKDRMAPTMEN1 | |
| SCHEMBL6240412 | 0.83 | ABCG2 (0.41) | CDC7ALKCDK1KDRMAPT | |
| SCHEMBL6270213 | 0.83 | FGFR1 (0.44) | KDRMAPTMEN1KMT2ALMNA | |
| SCHEMBL6683647 | 0.83 | PDE5A (0.41) | KDRMAPTMEN1NPC1RAB9A | |
| SCHEMBL6237608 | 0.81 | CDC7 (0.35) | CDC7ALKCDK1KDRMAPT | |
| SCHEMBL6235443 | 0.80 | TP53 (0.41) | PDE4BMAPTNPC1RAB9AKMT2A | |
| SCHEMBL6684324 | 0.76 | MKNK1 (0.45) | CDK1MAPTRAB9ATDP1MAPK1 | |
| SCHEMBL6881613 | 0.75 | CDC7 (0.49) | CDC7ALKCDK1KDRMAPKAPK2 | |
| SCHEMBL6876454 | 0.73 | PTK2 (0.40) | CDK1MAPTLMNAPIM1 | |
| SCHEMBL9986916 | 0.70 | TNNI3K (0.59) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0836613-B1 | WATER-SOLUBLE ADENOSINE KINASE INHIBITORS | METABASIS THERAPEUTICS INC (US) | 2005-05-25 | — | — | EP | disclosed |
| EP-0836613-A1 | WATER-SOLUBLE ADENOSINE KINASE INHIBITORS | GENSIA, INC. (US) | 1998-04-22 | — | — | EP | disclosed |
| WO-1996040707-A1 | WATER-SOLUBLE ADENOSINE KINASE INHIBITORS | GENSIA SICOR (US) | 1996-12-19 | — | — | WO | disclosed |