Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | PTPRE | P23469 | 1/20 | 0.39 |
| ▸ | HPN | P05981 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GLS | O94925 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6079773 | 0.91 | MAPT (0.44) | MAPTMEN1KMT2AHTTPTPRE | |
| SCHEMBL6204115 | 0.87 | PTPRE (0.41) | MAPTMEN1KMT2AHTTPTPRE | |
| SCHEMBL6079234 | 0.82 | ABL1 (0.54) | MAPTMEN1KMT2AHTTPOLB | |
| SCHEMBL6080735 | 0.78 | BLM (0.55) | MAPTMEN1KMT2AHTTPOLB | |
| SCHEMBL6309454 | 0.75 | NPC1 (0.43) | MAPTMEN1KMT2APTPREHPN | |
| SCHEMBL6079515 | 0.75 | BLM (0.42) | MAPTMEN1KMT2AHTTPTPRE | |
| SCHEMBL6078723 | 0.75 | BLM (0.43) | MAPTMEN1KMT2AHTTPTPRE | |
| SCHEMBL6079674 | 0.75 | RAB9A (0.49) | MAPTMEN1KMT2AHTTPTPRE | |
| SCHEMBL6078996 | 0.75 | BRAF (0.50) | MAPTPTPREPOLBBLM | |
| SCHEMBL6084065 | 0.71 | CNR1 (0.53) | MAPTMEN1KMT2AHTTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005002673-A1 | RAF KINASE INHIBITORS | ASTEX THERAPEUTICS LIMITED (GB) | 2005-01-13 | — | — | WO | disclosed |