Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.51 |
| ▸ | PTPN5 | P54829 | 3/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | CASR | P41180 | 1/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.49 |
| ▸ | AKR1C2 | P52895 | 4/20 | 0.49 |
| ▸ | MGLL | Q99685 | 3/20 | 0.46 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.46 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.46 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.46 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.46 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.46 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.46 |
| ▸ | KIF11 | P52732 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.45 |
| ▸ | RXRA | P19793 | 1/20 | 0.43 |
| ▸ | RXRB | P28702 | 1/20 | 0.43 |
| ▸ | RXRG | P48443 | 1/20 | 0.43 |
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5791303 | 0.86 | AKR1C3 (0.55) | PTPN5PTGS1PTGS2AKR1C3AKR1C2 | |
| SCHEMBL5033496 | 0.86 | PTGS2 (0.66) | PTGS1PTGS2PSEN1PSEN2APH1B | |
| SCHEMBL6270587 | 0.85 | AKR1C3 (0.63) | HDAC4PTPN5PTGS2AKR1C3AKR1C2 | |
| SCHEMBL15947827 | 0.84 | PTGS1 (0.56) | PTGS1PTGS2AKR1C3AKR1C2 | |
| SCHEMBL5039701 | 0.83 | PTGS1 (0.66) | PTGS1PTGS2PSEN1PSEN2APH1B | |
| SCHEMBL8078579 | 0.81 | HPGD (0.50) | PTGS1PTGS2AKR1C3AKR1C2 | |
| SCHEMBL2274626 | 0.78 | PTPN5 (0.69) | HDAC4PTPN5CASRPSEN1PSEN2 | |
| SCHEMBL2274629 | 0.78 | PTPN5 (0.69) | HDAC4PTPN5CASRPSEN1PSEN2 | |
| SCHEMBL2274622 | 0.78 | PTPN5 (0.69) | HDAC4PTPN5CASRPSEN1PSEN2 | |
| SCHEMBL6477785 | 0.78 | PSEN1 (0.54) | HDAC4PTPN5CASRAKR1C3AKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1604970-A1 | 2-(Biphenyl-3-yl)-carboxylic acids of gamma-secretase-modulating activity | CELLZOME AG (DE) | 2005-12-14 | — | — | EP | disclosed |
| WO-2005110963-A1 | (BIPHENYL-3-YL)-CARBOXYLIC ACIDS AND DERIVATIVES THEREOF AND THEIR USE IN THERAPY | CELLZOME AG (DE) | 2005-11-24 | — | — | WO | disclosed |