Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | F9 | P00740 | 1/20 | 0.50 |
| ▸ | AKR1C3 | P42330 | 6/20 | 0.49 |
| ▸ | AKR1C2 | P52895 | 6/20 | 0.49 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.49 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.49 |
| ▸ | MMP12 | P39900 | 2/20 | 0.48 |
| ▸ | MMP13 | P45452 | 1/20 | 0.48 |
| ▸ | RXRA | P19793 | 1/20 | 0.47 |
| ▸ | RXRB | P28702 | 1/20 | 0.47 |
| ▸ | RXRG | P48443 | 1/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1123024 | 0.86 | PTGS2 (0.59) | PTGS2PTGS1AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL1759907 | 0.84 | PTGS1 (0.65) | PTGS2PTGS1AKR1C3AKR1C2AKR1C4 | |
| SCHEMBL29537690 | 0.84 | PTGS1 (0.65) | PTGS2PTGS1AKR1C3AKR1C2AKR1C4 | |
| SCHEMBL1991313 | 0.84 | PTGS1 (0.65) | PTGS2PTGS1AKR1C3AKR1C2AKR1C4 | |
| SCHEMBL18069753 | 0.84 | F9 (0.48) | F9AKR1C2AKR1C1MMP12MMP13 | |
| SCHEMBL22888490 | 0.83 | PTPN5 (0.54) | F9MMP12MMP13RXRARXRB | |
| SCHEMBL14603498 | 0.82 | F9 (0.47) | F9AKR1C2AKR1C1MMP12MMP13 | |
| SCHEMBL6270587 | 0.82 | AKR1C3 (0.63) | PTGS2AKR1C3AKR1C2AKR1C4AKR1C1 | |
| SCHEMBL9680427 | 0.81 | PTGS2 (0.50) | PTGS2PTGS1AKR1C3AKR1C2APP | |
| SCHEMBL9680432 | 0.81 | PTGS2 (0.50) | PTGS2PTGS1AKR1C3AKR1C2APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1604970-A1 | 2-(Biphenyl-3-yl)-carboxylic acids of gamma-secretase-modulating activity | CELLZOME AG (DE) | 2005-12-14 | — | — | EP | disclosed |
| WO-2005110963-A1 | (BIPHENYL-3-YL)-CARBOXYLIC ACIDS AND DERIVATIVES THEREOF AND THEIR USE IN THERAPY | CELLZOME AG (DE) | 2005-11-24 | — | — | WO | disclosed |