Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 13/20 | 0.46 |
| ▸ | BCL6 | P41182 | 2/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL625686 | 0.86 | GRM2 (0.51) | GRM2BCL6ALDH1A1MAPT | |
| SCHEMBL14992415 | 0.84 | GRM2 (0.58) | GRM2GRIN1GRIN2BNPC1ALDH1A1 | |
| SCHEMBL627494 | 0.73 | GRM2 (0.44) | GRM2BCL6CYP1A2 | |
| SCHEMBL14992794 | 0.72 | GRM2 (0.59) | GRM2 | |
| SCHEMBL14991890 | 0.72 | GRM2 (0.56) | GRM2GRIN1GRIN2B | |
| SCHEMBL14992483 | 0.72 | GRM2 (0.58) | GRM2 | |
| SCHEMBL14992604 | 0.71 | GRM2 (0.45) | GRM2BCL6ALDH1A1CYP1A2 | |
| SCHEMBL628004 | 0.70 | GRM2 (0.59) | GRM2CYP1A2 | |
| SCHEMBL14992069 | 0.70 | GRM2 (0.56) | GRM2 | |
| SCHEMBL627348 | 0.70 | GRM2 (0.46) | GRM2BCL6GRIN1GRIN2BCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2603079-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 | Merck Sharp & Dohme Corp. (US) | 2013-06-19 | — | — | EP | claimed |
| WO-2012021382-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 | MERCK SHARP & DOHME CORP. (US) | 2012-02-16 | — | — | WO | claimed |