Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 14/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.40 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | BCL6 | P41182 | 2/20 | 0.37 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.37 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL627293 | 0.86 | GRM2 (0.46) | GRM2ALDH1A1MAPTBCL6 | |
| SCHEMBL14992069 | 0.85 | GRM2 (0.56) | GRM2GAAPRMT5WDR77 | |
| SCHEMBL627494 | 0.71 | GRM2 (0.44) | GRM2BCL6GRIA2GRIA4 | |
| SCHEMBL625531 | 0.71 | GRM2 (0.42) | GRM2GAAKDM4EALDH1A1MAPT | |
| SCHEMBL14992794 | 0.71 | GRM2 (0.59) | GRM2 | |
| SCHEMBL14992483 | 0.70 | GRM2 (0.58) | GRM2PRMT5WDR77 | |
| SCHEMBL14992415 | 0.70 | GRM2 (0.58) | GRM2ALDH1A1 | |
| SCHEMBL14992713 | 0.69 | GRM2 (0.57) | GRM2GAA | |
| SCHEMBL10146567 | 0.69 | GRM2 (0.59) | GRM2GAA | |
| SCHEMBL14991890 | 0.69 | GRM2 (0.56) | GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2603079-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 | Merck Sharp & Dohme Corp. (US) | 2013-06-19 | — | — | EP | claimed |
| WO-2012021382-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 | MERCK SHARP & DOHME CORP. (US) | 2012-02-16 | — | — | WO | claimed |