SCHEMBL627299

SCHEMBL627299

CC(C)[C@H](N)C(=O)NC(CC(=O)OC(C)(C)C)C(O)COc1c(F)c(F)cc(F)c1F

nearest known ligand 0.37

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CYP2D6 P10635 1/20 0.37
CASP3 P42574 15/20 0.36
CASP6 P55212 14/20 0.36
CASP8 Q14790 14/20 0.36
CASP7 P55210 1/20 0.36
KDM4E B2RXH2 1/20 0.34
ALDH1A1 P00352 1/20 0.34
MAPT P10636 1/20 0.34
HTT P42858 1/20 0.34
AAK1 Q2M2I8 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL627300 1.00 CYP2D6 (0.37) CYP2D6CASP3CASP6CASP8CASP7
SCHEMBL4421626 1.00 CYP2D6 (0.37) CYP2D6CASP3CASP6CASP8CASP7
SCHEMBL23268871 0.92 CYP2D6 (0.36) CYP2D6CASP3CASP6CASP8CASP7
SCHEMBL4424248 0.92 CYP2D6 (0.36) CYP2D6CASP3CASP6CASP8CASP7
SCHEMBL7199035 0.86 CASP3 (0.45) CASP3CASP6CASP8CASP7
SCHEMBL12716141 0.83 CYP2D6 (0.35) CYP2D6CASP3CASP6CASP8CASP7
SCHEMBL20827204 0.83 MAPT (0.36) CYP2D6CASP3CASP6CASP8CASP7
SCHEMBL7357612 0.81 MAPK1 (0.40) CASP3CASP6CASP8ALDH1A1
SCHEMBL4420429 0.81 MAPK1 (0.40) CASP3CASP6CASP8ALDH1A1
SCHEMBL79263 0.81 MAPT (0.35) CYP2D6CASP3CASP6CASP8CASP7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012021800-A2 CASPASE INHIBITORS AS THERAPEUTICS FOR NEURAL AND ORGAN INJURY AND IMAGING BANYAN BIOMARKERS (US) 2012-02-16 WO disclosed
WO-2012021800-A2 CASPASE INHIBITORS AS THERAPEUTICS FOR NEURAL AND ORGAN INJURY AND IMAGING BANYAN BIOMARKERS (US) 2012-02-16 WO disclosed
EP-1351975-A2 C-TERMINAL MODIFIED OXAMYL DIPEPTIDES AS INHIBITORS OF THE ICE/CED-3 FAMILY OF CYSTEINE PROTEASES Idun Pharmaceuticals, Inc. (US) 2003-10-15 EP disclosed
WO-2002057298-A2 C-TERMINAL MODIFIED OXAMYL DIPEPTIDES AS INHIBITORS OF THE ICE/CED-3 FAMILY OF CYSTEINE PROTEASES IDUN PHARMACEUTICALS, INC. (US) 2002-07-25 WO disclosed