Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CETP | P11597 | 9/20 | 0.40 |
| ▸ | PDE2A | O00408 | 3/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6430199 | 1.00 | CETP (0.40) | CETPPDE2AADRB2ADRB1SMN1; SMN2 | |
| SCHEMBL1904229 | 0.95 | CETP (0.41) | CETPPDE2ALMNA | |
| SCHEMBL5669194 | 0.95 | CETP (0.41) | CETPPDE2ALMNA | |
| SCHEMBL6274625 | 0.93 | CETP (0.41) | CETPPDE2A | |
| SCHEMBL994517 | 0.93 | CETP (0.41) | CETPPDE2A | |
| SCHEMBL6435008 | 0.92 | CETP (0.40) | CETPADRB2ADRB1SMN1; SMN2LMNA | |
| SCHEMBL6064713 | 0.92 | CETP (0.40) | CETPADRB2ADRB1SMN1; SMN2LMNA | |
| SCHEMBL5669024 | 0.91 | PDE2A (0.42) | CETPPDE2ASMN1; SMN2LMNA | |
| SCHEMBL1899039 | 0.91 | PDE2A (0.42) | CETPPDE2ASMN1; SMN2LMNA | |
| SCHEMBL5668949 | 0.91 | CETP (0.40) | CETPPDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005117869-A1 | COMBINATIONS COMPRISING (S)-AMLODIPINE AND A CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITOR, AND METHODS FOR REDUCING HYPERTENSION | SEPRACOR INC. (US) | 2005-12-15 | — | — | WO | disclosed |
| EP-1578448-A1 | COMPOSITIONS OF CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS AND HMG-COA REDUCTASE INHIBITORS | Pfizer Products Inc. (US) | 2005-09-28 | — | — | EP | disclosed |
| WO-2004056395-A1 | COMPOSITIONS OF CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS AND HMG-COA REDUCTASE INHIBITORS | PFIZER PRODUCTS INC. (US) | 2004-07-08 | — | — | WO | disclosed |