Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 9/20 | 0.50 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.39 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.37 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.37 |
| ▸ | BMPR1A | P36894 | 2/20 | 0.37 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1946265 | 0.85 | FYN (0.68) | FYNHASPIN | |
| SCHEMBL1946951 | 0.84 | FYN (0.60) | FYNMAPTMEN1NPC1TP53 | |
| SCHEMBL1944216 | 0.83 | MAPT (0.51) | FYNMAPTNPC1TP53RAB9A | |
| SCHEMBL1946929 | 0.82 | TP53 (0.51) | FYNMAPTMEN1NPC1TP53 | |
| SCHEMBL627440 | 0.81 | FYN (0.45) | FYN | |
| SCHEMBL1946144 | 0.81 | PIM1 (0.48) | FYNNPC1TP53RAB9ASMN1; SMN2 | |
| SCHEMBL1944689 | 0.80 | FYN (0.65) | FYNKDM4EALDH1A1 | |
| SCHEMBL1945407 | 0.80 | FYN (0.46) | FYNMAPTMEN1NPC1TP53 | |
| SCHEMBL627335 | 0.80 | FYN (0.74) | FYNHASPIN | |
| SCHEMBL627333 | 0.80 | FYN (0.74) | FYNHASPIN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020215-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |