Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE known ✓ | P12821 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | TSHR | P16473 | 2/20 | 0.61 |
| ▸ | BLM | P54132 | 2/20 | 0.61 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | MPO | P05164 | 1/20 | 0.61 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ECE1 | P42892 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dl-Tryptophan SCHEMBL22495172 | 1.00 | KDM4E (0.61) | KDM4EMAPTLMNATSHRBLM | |
| Dl-Tryptophan SCHEMBL28512622 | 0.95 | KDM4E (0.68) | KDM4EMAPTLMNATSHRBLM | |
| Tryptophan SCHEMBL530950 | 0.95 | KDM4E (0.68) | KDM4EMAPTLMNATSHRBLM | |
| Dl-Tryptophan SCHEMBL27136864 | 0.95 | KDM4E (0.68) | KDM4EMAPTLMNATSHRBLM | |
| Dl-Tryptophan SCHEMBL28518234 | 0.95 | KDM4E (0.68) | KDM4EMAPTLMNATSHRBLM | |
| Dl-Tryptophan SCHEMBL28798150 | 0.95 | KDM4E (0.68) | KDM4EMAPTLMNATSHRBLM | |
| Dl-Tryptophan SCHEMBL20164946 | 0.95 | KDM4E (0.68) | KDM4EMAPTLMNATSHRBLM | |
| Dl-Tryptophan SCHEMBL1533586 | 0.95 | KDM4E (0.68) | KDM4EMAPTLMNATSHRBLM | |
| Tryptophan SCHEMBL27622251 | 0.95 | KDM4E (0.68) | KDM4EMAPTLMNATSHRBLM | |
| Dl-Tryptophan SCHEMBL28468559 | 0.94 | KDM4E (0.54) | KDM4EMAPTLMNATSHRBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005110009-A2 | COMPOSITIONS AND METHODS RELATING TO TSP-30a, b, c AND d | IMMUNEX CORPORATION (US) | 2005-11-24 | — | — | WO | disclosed |
| US-20050054829-A1 | Compositions and methods relating to TSP-30a, b, c and d | IMMUNEX CORPORATION | 2005-03-10 | — | — | US | disclosed |