Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.68 |
| ▸ | MAPT | P10636 | 3/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.68 |
| ▸ | LMNA | P02545 | 2/20 | 0.68 |
| ▸ | TSHR | P16473 | 2/20 | 0.68 |
| ▸ | BLM | P54132 | 2/20 | 0.68 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.68 |
| ▸ | MEN1 | O00255 | 2/20 | 0.68 |
| ▸ | MPO | P05164 | 1/20 | 0.68 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dl-Tryptophan SCHEMBL27136864 | 1.00 | KDM4E (0.68) | KDM4EMAPTKMT2ALMNATSHR | |
| Dl-Tryptophan SCHEMBL1533586 | 1.00 | KDM4E (0.68) | KDM4EMAPTKMT2ALMNATSHR | |
| Tryptophan SCHEMBL27622251 | 1.00 | KDM4E (0.68) | KDM4EMAPTKMT2ALMNATSHR | |
| Dl-Tryptophan SCHEMBL28518234 | 1.00 | KDM4E (0.68) | KDM4EMAPTKMT2ALMNATSHR | |
| Dl-Tryptophan SCHEMBL28798150 | 1.00 | KDM4E (0.68) | KDM4EMAPTKMT2ALMNATSHR | |
| Dl-Tryptophan SCHEMBL28512622 | 1.00 | KDM4E (0.68) | KDM4EMAPTKMT2ALMNATSHR | |
| Dl-Tryptophan SCHEMBL20164946 | 1.00 | KDM4E (0.68) | KDM4EMAPTKMT2ALMNATSHR | |
| Dl-Tryptophan SCHEMBL27660745 | 0.96 | KMT2A (0.63) | KDM4EMAPTKMT2ALMNATSHR | |
| Dl-Tryptophan SCHEMBL28130701 | 0.96 | KDM4E (0.63) | KDM4EMAPTKMT2ALMNATSHR | |
| Tryptophan SCHEMBL6274044 | 0.95 | KDM4E (0.61) | KDM4EMAPTKMT2ALMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 153 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116593518-A | Amino acid identification and content determination method | 浙江博锐生物制药有限公司 | 2023-08-15 | — | — | CN | claimed |
| CN-114566292-B | Construction method of model for predicting kidney transplantation drug dosage by using endogenous substances | 浙江大学医学院附属第一医院 | 2022-11-11 | — | — | CN | claimed |
| CN-114566292-A | Construction method of model for predicting kidney transplantation medicine dosage by using endogenous substances | 浙江大学医学院附属第一医院 | 2022-05-31 | — | — | CN | claimed |
| CN-112457385-B | Application of gene LJP1 for controlling rice growth period | 福建农林大学 | 2022-04-08 | — | — | CN | claimed |
| CN-111533789-B | Tryptophan and lysine chain-crossing interaction beta-hairpin antibacterial peptide and preparation method thereof | 东北农业大学 | 2021-12-14 | — | — | CN | claimed |
| CN-112457385-A | Application of gene LJP1 for controlling rice growth period | 福建农林大学 | 2021-03-09 | — | — | CN | claimed |
| CN-111533789-A | Tryptophan and lysine chain-crossing interaction beta-hairpin antibacterial peptide and preparation method thereof | 东北农业大学 | 2020-08-14 | — | — | CN | claimed |
| US-9164106-B2 | Determination of decreased metabolism of tryptophan in diagnosis of autism spectrum disorders | GREENWOOD GENETIC CENTER, INC. (US) | 2015-10-20 | — | — | US | claimed |
| EP-1642910-B1 | Rationally designed antibodies | ALEXION PHARMA INC (US) | 2012-02-08 | — | — | EP | claimed |
| EP-1370589-B1 | RATIONALLY DESIGNED ANTIBODIES | ALEXION PHARMA INC (US) | 2006-03-15 | — | — | EP | claimed |
| US-20240240197-A1 | HERBICIDE-TOLERANT PLANTS | BASF SE (DE) | 2024-07-18 | — | — | US | disclosed |
| CN-110831624-B | Compositions and methods for tumor vaccination and immunotherapy involving HER antigens | 埃特彼塞斯公司 | 2024-04-16 | — | — | CN | disclosed |
| EP-3401395-B1 | HERBICIDE-TOLERANT PLANTS | BASF AGROCHEMICAL PRODUCTS BV (NL) | 2024-01-17 | — | — | EP | disclosed |
| US-20230404009-A9 | METHOD FOR TREATING POST-EMERGENT RICE | BASF AGROCHEMICAL PRODUCTS, B.V. (NL) | 2023-12-21 | — | — | US | disclosed |
| EP-2997133-B1 | METHODS FOR ENGINEERING HIGHLY ACTIVE T CELL FOR IMMUNOTHERAPY | CELLECTIS (FR) | 2023-08-23 | — | — | EP | disclosed |
| US-20030049699-A1 | Polypeptide (MBP1) capable of interacting with oncogenic mutants of the P53 protein | CONSEILLER EMMANUEL (FR) | 2003-03-13 | — | — | US | disclosed |
| US-6268516-B1 | AS GENE TRANSFER VEHICLES IN VITRO AND IN VIVO | MAX-DELBRUCK-CENTRUM FUR MOLEKULARE MEDIZIN (DE) | 2001-07-31 | — | — | US | disclosed |
| CN-1108551-A | Animal serum health-care medicine containing traditional Chinese medicine and preparation method thereof | ZHOU FENG (CN) | 1995-09-20 | — | — | CN | disclosed |
| EP-0500589-A1 | PURIFIED PROTEIN AND BIOACTIVE PHARMACEUTICAL. | ALFACELL CORP (US) | 1992-09-02 | — | — | EP | disclosed |
| WO-1991007435-A1 | PURIFIED PROTEIN AND BIOACTIVE PHARMACEUTICAL | ALFACELL CORPORATION (US) | 1991-05-30 | — | — | WO | disclosed |