Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 4/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | MAP3K12 | Q12852 | 5/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL627466 | 1.00 | HASPIN (0.43) | HASPINFYNPIK3CAPIK3CDPIK3CB | |
| SCHEMBL627323 | 0.92 | FYN (0.48) | FYNPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL627321 | 0.92 | FYN (0.48) | FYNPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL626796 | 0.87 | PIK3CA (0.39) | HASPINFYNPIK3CAPIK3CDPIK3CB | |
| SCHEMBL627467 | 0.87 | HASPIN (0.43) | HASPINFYNPIK3CAPIK3CDPIK3CB | |
| SCHEMBL626188 | 0.86 | MAP3K12 (0.41) | PIK3CAMAP3K12 | |
| SCHEMBL628257 | 0.83 | DPP4 (0.38) | FYNPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL628259 | 0.83 | DPP4 (0.38) | FYNPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL627322 | 0.79 | FYN (0.48) | FYNPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL625108 | 0.76 | CDK2 (0.42) | PIK3CAPIK3CDPIK3CBPIK3CGMAP3K12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020215-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |