Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 10/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 9/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 6/20 | 0.40 |
| ▸ | PI4KB | Q9UBF8 | 6/20 | 0.38 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.36 |
| ▸ | PIK3C2G | O75747 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | PI4KA | P42356 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2396147 | 0.86 | MEN1 (0.56) | MEN1KMT2APIK3CDPIK3CGPIK3CA | |
| SCHEMBL2393257 | 0.79 | MEN1 (0.43) | MEN1KMT2APIK3CDPIK3CGPIK3CA | |
| SCHEMBL2395028 | 0.76 | PIK3CD (0.49) | PIK3CDPIK3CGPIK3CAPI4KBPIK3C2G | |
| SCHEMBL2397546 | 0.75 | PIK3C2G (0.47) | MEN1KMT2APIK3CDPIK3CGPIK3CA | |
| SCHEMBL2398117 | 0.73 | PIK3CD (0.50) | MEN1KMT2APIK3CDPIK3CGPIK3CA | |
| SCHEMBL2395156 | 0.73 | CDK2 (0.59) | MEN1KMT2APIK3CDPIK3CGPIK3CA | |
| SCHEMBL2398032 | 0.71 | PIK3CD (0.47) | MEN1KMT2APIK3CDPIK3CGPIK3CA | |
| SCHEMBL6276191 | 0.71 | CDK2 (0.41) | MEN1KMT2APIK3CDPIK3CGPIK3CA | |
| SCHEMBL2394578 | 0.71 | MEN1 (0.55) | MEN1KMT2APIK3CDPIK3CGPIK3CA | |
| SCHEMBL2395275 | 0.69 | PIK3CD (0.62) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1608647-A1 | 5-PHENYLTHIAZOLE DERIVATIVES AND THEIR USE AS P13 KINASE INHIBITORS | Novartis AG (CH) | 2005-12-28 | — | — | EP | disclosed |
| WO-2004078754-A1 | 5-PHENYLTHIAZOLE DERIVATIVES AND THEIR USE AS P13 KINASE INHIBITORS | NOVARTIS AG (CH) | 2004-09-16 | — | — | WO | disclosed |