Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 4/20 | 0.41 |
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 7/20 | 0.40 |
| ▸ | CA2 | P00918 | 7/20 | 0.40 |
| ▸ | CA9 | Q16790 | 6/20 | 0.40 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 3/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2396147 | 0.82 | MEN1 (0.56) | CDK2CA1CA2CA9MEN1 | |
| SCHEMBL22792359 | 0.75 | CA1 (0.59) | CA1CA2CA9CA12CA7 | |
| SCHEMBL2393257 | 0.73 | MEN1 (0.43) | MEN1KMT2AKDM4EMAPTPIK3CD | |
| SCHEMBL6276205 | 0.71 | MEN1 (0.41) | MEN1KMT2AKDM4EMAPTPIK3CD | |
| SCHEMBL2395156 | 0.70 | CDK2 (0.59) | CDK2MEN1KMT2AKDM4EPOLB | |
| SCHEMBL6274171 | 0.68 | PIK3CD (0.54) | CDK2PDE5AMEN1KMT2AKDM4E | |
| SCHEMBL2397546 | 0.68 | PIK3C2G (0.47) | MEN1KMT2APIK3CDPIK3CAPIK3CB | |
| SCHEMBL4596247 | 0.65 | PIK3CD (0.53) | CDK2PDE5ACA1CA2CA9 | |
| SCHEMBL2394578 | 0.65 | MEN1 (0.55) | CDK2CA1CA2CA9MEN1 | |
| SCHEMBL6189377 | 0.65 | MEN1 (0.49) | CDK2CA1CA2CA9MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1608647-A1 | 5-PHENYLTHIAZOLE DERIVATIVES AND THEIR USE AS P13 KINASE INHIBITORS | Novartis AG (CH) | 2005-12-28 | — | — | EP | disclosed |
| WO-2004078754-A1 | 5-PHENYLTHIAZOLE DERIVATIVES AND THEIR USE AS P13 KINASE INHIBITORS | NOVARTIS AG (CH) | 2004-09-16 | — | — | WO | disclosed |