Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.53 |
| ▸ | ENPP2 | Q13822 | 4/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | TACR3 | P29371 | 3/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.36 |
| ▸ | CCR1 | P32246 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6262225 | 1.00 | KCNH2 (0.53) | KCNH2ENPP2PTGDR2TACR3HCRTR1 | |
| SCHEMBL5958596 | 0.90 | KCNH2 (0.62) | KCNH2ENPP2TACR3HCRTR1HCRTR2 | |
| SCHEMBL5958631 | 0.90 | KCNH2 (0.62) | KCNH2ENPP2TACR3HCRTR1HCRTR2 | |
| SCHEMBL5958598 | 0.90 | KCNH2 (0.62) | KCNH2ENPP2TACR3HCRTR1HCRTR2 | |
| SCHEMBL27632657 | 0.79 | KCNH2 (0.47) | KCNH2ENPP2HCRTR1HCRTR2TP53 | |
| SCHEMBL27632648 | 0.79 | KCNH2 (0.47) | KCNH2ENPP2HCRTR1HCRTR2TP53 | |
| SCHEMBL5958641 | 0.78 | KCNH2 (0.84) | KCNH2LMNA | |
| SCHEMBL16399817 | 0.77 | ENPP2 (0.49) | KCNH2ENPP2PTGDR2CCR1MGLL | |
| SCHEMBL6192915 | 0.77 | KCNH2 (0.59) | KCNH2MAPTLMNAGRM2 | |
| SCHEMBL5958617 | 0.75 | KCNH2 (0.62) | KCNH2TP53MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005077373-A2 | TREATMENT OF GASTRO-ESOPHAGEAL REFLUX DISEASE (GERD) | ASTRAZENECA AB (SE) | 2005-08-25 | — | — | WO | claimed |