Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 18/20 | 0.70 |
| ▸ | CYP2D6 | P10635 | 14/20 | 0.70 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.70 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.51 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.51 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.51 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6416790 | 0.82 | HRH1 (1.00) | HRH1CYP2D6KCNH2CHRM1CHRM2 | |
| SCHEMBL6420059 | 0.81 | HRH1 (0.71) | HRH1CYP2D6KCNH2CHRM1CHRM2 | |
| SCHEMBL6414675 | 0.79 | HRH1 (0.81) | HRH1CYP2D6KCNH2CHRM1CHRM2 | |
| SCHEMBL6414149 | 0.77 | HRH1 (0.62) | HRH1CYP2D6KCNH2CHRM1CHRM2 | |
| SCHEMBL6272623 | 0.76 | HRH1 (0.64) | HRH1CYP2D6KCNH2CHRM1CHRM2 | |
| SCHEMBL6272673 | 0.70 | HRH1 (0.64) | HRH1CYP2D6KCNH2CHRM1CHRM2 | |
| SCHEMBL6418598 | 0.70 | HRH1 (0.57) | HRH1CYP2D6KCNH2CHRM1CHRM2 | |
| SCHEMBL6279164 | 0.69 | HRH1 (1.00) | HRH1CYP2D6KCNH2CHRM1CHRM2 | |
| SCHEMBL6274077 | 0.68 | HRH1 (0.76) | HRH1CYP2D6KCNH2CHRM1CHRM2 | |
| SCHEMBL6414581 | 0.68 | HRH1 (0.74) | HRH1CYP2D6KCNH2CHRM1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005097093-A1 | SLEEP INDUCING COMPOUNDS AND METHODS RELATING THERETO | NEUROCRINE BIOSCIENCES, INC. (US) | 2005-10-20 | — | — | WO | claimed |