Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 16/20 | 0.74 |
| ▸ | CYP2D6 | P10635 | 11/20 | 0.74 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.74 |
| ▸ | CHRM1 | P11229 | 9/20 | 0.69 |
| ▸ | CHRM2 | P08172 | 8/20 | 0.56 |
| ▸ | CHRM4 | P08173 | 8/20 | 0.56 |
| ▸ | CHRM5 | P08912 | 8/20 | 0.56 |
| ▸ | CHRM3 | P20309 | 8/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.53 |
| ▸ | DRD1 | P21728 | 1/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6416790 | 0.85 | HRH1 (1.00) | HRH1CYP2D6KCNH2CHRM1CHRM2 | |
| SCHEMBL6279164 | 0.83 | HRH1 (1.00) | HRH1CYP2D6KCNH2CHRM1CHRM2 | |
| SCHEMBL6276908 | 0.82 | HRH1 (1.00) | HRH1CYP2D6KCNH2CHRM1CHRM2 | |
| SCHEMBL6417406 | 0.80 | HRH1 (0.75) | HRH1CYP2D6KCNH2CHRM1CHRM2 | |
| SCHEMBL6270434 | 0.80 | HRH1 (0.63) | HRH1CYP2D6KCNH2CHRM1CHRM2 | |
| SCHEMBL6414675 | 0.76 | HRH1 (0.81) | HRH1CYP2D6KCNH2CHRM1CHRM2 | |
| SCHEMBL6274077 | 0.76 | HRH1 (0.76) | HRH1CYP2D6KCNH2CHRM1CHRM2 | |
| SCHEMBL6272673 | 0.75 | HRH1 (0.64) | HRH1CYP2D6KCNH2CHRM1CHRM2 | |
| SCHEMBL6277629 | 0.74 | HRH1 (0.82) | HRH1CYP2D6KCNH2CHRM1CHRM2 | |
| SCHEMBL6278192 | 0.72 | HRH1 (1.00) | HRH1CYP2D6KCNH2CHRM1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050277645-A1 | Sleep inducing compounds and methods relating thereto | NEUROCRINE BIOSCIENCES, INC. (US) | 2005-12-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050277645-A1 | Sleep inducing compounds and methods relating thereto | CNR1, CNR2, MTNR1B | HRH1 104/4885CYP2D6 74/4885KCNH2 1127/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.