Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV3 | Q8NET8 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL624839 | 0.87 | TRPV3 (0.55) | TRPV3NR1I2KDM4EKCNA5TP53 | |
| SCHEMBL624448 | 0.81 | TRPV3 (0.66) | TRPV3NR1I2KDM4EKCNA5TP53 | |
| SCHEMBL624783 | 0.81 | TRPV3 (0.65) | TRPV3LMNANR1I2KDM4EKCNA5 | |
| SCHEMBL624769 | 0.76 | TRPV3 (0.55) | TRPV3NR1I2NPSR1KDM4EKCNA5 | |
| SCHEMBL625185 | 0.75 | TRPV3 (0.60) | TRPV3NR1I2CHRM2CHRM4CHRM5 | |
| SCHEMBL625260 | 0.73 | TRPV3 (0.52) | TRPV3NR1I2PDK2KDM4EKCNA5 | |
| SCHEMBL625811 | 0.72 | TRPV3 (0.65) | TRPV3LMNANR1I2ALDH1A1CYP1A2 | |
| SCHEMBL624475 | 0.71 | TRPV3 (0.53) | TRPV3NR1I2MAPTNPSR1 | |
| SCHEMBL624476 | 0.71 | TRPV3 (0.53) | TRPV3NR1I2MAPTNPSR1 | |
| SCHEMBL14956815 | 0.70 | TRPV3 (0.66) | TRPV3NR1I2KDM4EKCNA5KCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2603490-A1 | NOVEL TRPV3 MODULATORS | AbbVie Inc. (US) | 2013-06-19 | — | — | EP | disclosed |
| WO-2012019315-A1 | NOVEL TRPV3 MODULATORS | ABBOTT LABORATORIES (US) | 2012-02-16 | — | — | WO | disclosed |