⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9835411 | 0.92 | — | — | |
| SCHEMBL300224 | 0.82 | — | — | |
| SCHEMBL7771422 | 0.76 | — | — | |
| SCHEMBL1170826 | 0.76 | — | — | |
| SCHEMBL8011163 | 0.74 | — | — | |
| SCHEMBL5341058 | 0.74 | — | — | |
| SCHEMBL563582 | 0.74 | — | — | |
| SCHEMBL116689 | 0.72 | — | — | |
| SCHEMBL9643826 | 0.72 | — | — | |
| SCHEMBL4968791 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0275901-B1 | USE OF GAMMA-GLUTAMYL-TRANSPEPTIDASE | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-06-09 | — | — | EP | claimed |
| US-4990444-A | Fermentation of bacteria; used for hydrolysis of (adipinyl-or glutaryl)-7-aminocephalosporanic acid | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-02-05 | — | — | US | claimed |
| EP-1322751-B1 | GLUTARYL CEPHALOSPORIN AMIDASE FROM PSEUDOMONAS DIMINUTA BS-203 | BRISTOL MYERS SQUIBB CO (US) | 2005-11-23 | — | — | EP | disclosed |
| US-6942990-B2 | Glutaryl cephalosporin amidase from Pseudomonas diminuta BS-203 | BRISTOL MYERS SQUIBB COMPANY (US) | 2005-09-13 | — | — | US | disclosed |
| US-20030143715-A1 | Glutaryl cephalosporin amidase from pseudomonas diminuta BS-203 | BINDER ROSS (US) | 2003-07-31 | — | — | US | disclosed |
| EP-1322751-A2 | GLUTARYL CEPHALOSPORIN AMIDASE FROM PSEUDOMONAS DIMINUTA BS-203 | Bristol-Myers Squibb Company (US) | 2003-07-02 | — | — | EP | disclosed |
| US-6528300-B2 | For use in obtaining 7-aminocephalosporanic acid (7-ACA) from 7- beta -(4-carboxybutanamido)cephalosporanic acid (glutaryl 7-ACA) by enzymatic hydrolysis | BRISTOL-MYERS SQUIBB CO. | 2003-03-04 | — | — | US | disclosed |
| US-20020160500-A1 | Glutaryl cephalosporin amidase from pseudomonas diminuta BS-203 | BRISTOL-MEYERS SQUIBB COMPANY | 2002-10-31 | — | — | US | disclosed |
| WO-2002024879-A2 | GLUTARYL CEPHALOSPORIN AMIDASE FROM PSEUDOMONAS DIMINUTA BS-203 | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-03-28 | — | — | WO | disclosed |
| EP-0720611-A1 | GLUTARYL 7-ACA DERIVATIVES AND PROCESSES FOR OBTAINING THEM | ANTIBIOTICOS S.P.A. (IT) | 1996-07-10 | — | — | EP | disclosed |
| WO-1995035020-A2 | GLUTARYL 7-ACA DERIVATIVES AND PROCESSES FOR OBTAINING THEM | ANTIBIOTICOS S.P.A. (IT) | 1995-12-28 | — | — | WO | disclosed |
| EP-0605589-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING NATRIURETIC PEPTIDES OR NEUTRAL ENDOPEPTIDASE INHIBITORS FOR TREATING OR PREVENTING MYOINTIMAL PROLIFERATION | SCHERING CORPORATION (US) | 1994-07-13 | — | — | EP | disclosed |
| WO-1993010773-A1 | USE OF NEUTRAL ENDOPEPTIDASE INHIBITORS IN THE TREATMENT OF LEFT VENTRICULAR HYPERTROPHY | SCHERING-PLOUGH S.P.A. (IT) | 1993-06-10 | — | — | WO | disclosed |
| WO-1993005809-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING NATRIURETIC PEPTIDES OR NEUTRAL ENDOPEPTIDASE INHIBITORS FOR TREATING OR PREVENTING MYOINTIMAL PROLIFERATION | SCHERING CORPORATION (US) | 1993-04-01 | — | — | WO | disclosed |
| EP-0533084-A1 | Pharmaceutical compositions comprising natriuretic peptides or neutral endopeptidase inhibitors for treating and preventing myointimal proliferation | SCHERING CORPORATION (US) | 1993-03-24 | — | — | EP | disclosed |
| WO-1992018159-A1 | USE OF NEUTRAL ENDOPEPTIDASE INHIBITORS IN THE TREATMENT OF NEPHROTOXICITY | SCHERING CORPORATION (US) | 1992-10-29 | — | — | WO | disclosed |
| EP-0509442-A1 | Use of neutral endopeptidase inhibitors in the treatment of nephrotoxicity | SCHERING CORPORATION (US) | 1992-10-21 | — | — | EP | disclosed |
| US-4990444-A | Fermentation of bacteria; used for hydrolysis of (adipinyl-or glutaryl)-7-aminocephalosporanic acid | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-02-05 | — | — | US | disclosed |
| US-4990444-A | Fermentation of bacteria; used for hydrolysis of (adipinyl-or glutaryl)-7-aminocephalosporanic acid | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-02-05 | — | — | US | disclosed |
| EP-0275901-A2 | Use of gamma-glutamyl-transpeptidase | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-07-27 | — | — | EP | disclosed |