Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 9/20 | 0.56 |
| ▸ | FLT1 | P17948 | 6/20 | 0.56 |
| ▸ | ITK | Q08881 | 6/20 | 0.51 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.51 |
| ▸ | FLT3 | P36888 | 2/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.51 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.51 |
| ▸ | CDK2 | P24941 | 2/20 | 0.51 |
| ▸ | PLK4 | O00444 | 1/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | CHUK | O15111 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | PAK4 | O96013 | 1/20 | 0.51 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.51 |
| ▸ | PRKCG | P05129 | 1/20 | 0.51 |
| ▸ | INSR | P06213 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5951797 | 0.86 | FGFR1 (0.58) | FGFR1FLT1ITKPDPK1FLT3 | |
| SCHEMBL3539166 | 0.84 | FGFR1 (0.56) | FGFR1FLT1ITKPDPK1FLT3 | |
| SCHEMBL5951886 | 0.76 | FGFR1 (0.63) | FGFR1FLT1ITKPDPK1FLT3 | |
| SCHEMBL4656189 | 0.76 | RPS6KA3 (0.51) | RPS6KA3GAA | |
| SCHEMBL3537073 | 0.73 | FGFR1 (0.71) | FGFR1FLT1ITKPDPK1FLT3 | |
| SCHEMBL5951751 | 0.73 | PDPK1 (0.80) | FGFR1FLT1ITKPDPK1FLT3 | |
| SCHEMBL4912661 | 0.72 | FGFR1 (0.70) | FGFR1FLT1ITKPDPK1FLT3 | |
| SCHEMBL29714859 | 0.72 | FGFR1 (1.00) | FGFR1FLT1ITKPDPK1FLT3 | |
| SCHEMBL311148 | 0.72 | FGFR1 (1.00) | FGFR1FLT1ITKPDPK1FLT3 | |
| SCHEMBL18562045 | 0.72 | CDK2 (0.53) | FGFR1FLT1ITKCHEK1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6897208-B2 | Benzimidazoles | AVENTIS PHARMACEUTICALS INC. (US) | 2005-05-24 | — | — | US | disclosed |