Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.36 |
| ▸ | CDK7 | P50613 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.36 |
| ▸ | LATS1 | O95835 | 1/20 | 0.35 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.35 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 6/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6280409 | 0.85 | ADORA2A (0.34) | LATS1LATS2MAPKAPK2KDM4CGPR55 | |
| SCHEMBL25169867 | 0.72 | ABL1 (0.54) | ABL1PDGFRACSNK1A1CDK7BTK | |
| SCHEMBL6285208 | 0.69 | KDM4E (0.46) | ABL1PDGFRACSNK1A1CDK7BTK | |
| SCHEMBL25420134 | 0.63 | PIM1 (0.44) | KDM4EHSD17B10PIM1NR3C2 | |
| SCHEMBL6280307 | 0.61 | KDM4E (0.57) | ABL1PDGFRACSNK1A1CDK7BTK | |
| SCHEMBL12143606 | 0.59 | BRD4 (0.33) | KDM4EHSD17B10 | |
| SCHEMBL14030401 | 0.58 | MEN1 (0.40) | — | |
| SCHEMBL23458576 | 0.57 | KDM4E (0.67) | ABL1PDGFRACSNK1A1CDK7BTK | |
| SCHEMBL12288275 | 0.57 | NPC1 (0.43) | GPR55 | |
| SCHEMBL25421165 | 0.57 | KDM4E (0.53) | ABL1PDGFRACSNK1A1CDK7BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6921762-B2 | Substituted indolizine-like compounds and methods of use | AMGEN INC. (US) | 2005-07-26 | — | — | US | disclosed |