Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.32 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.31 |
| ▸ | LATS1 | O95835 | 1/20 | 0.31 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.31 |
| ▸ | TACR1 | P25103 | 1/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | VNN1 | O95497 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | CASP3 | P42574 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.30 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6280395 | 0.85 | ABL1 (0.36) | MAPK1MAPK10GPR55NR3C2LATS1 | |
| SCHEMBL11391249 | 0.74 | POLB (0.49) | ADORA2AMAPK1ALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL6286431 | 0.72 | MAPK9 (0.42) | ALDH1A1MAPK10 | |
| SCHEMBL23176173 | 0.61 | SMN1; SMN2 (0.40) | ADORA2AMAPK1ALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL21672427 | 0.61 | SMN1; SMN2 (0.33) | SMN1; SMN2MEN1KMT2A | |
| SCHEMBL23331067 | 0.59 | TOP2A (0.35) | MAPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL12288275 | 0.58 | NPC1 (0.43) | SMN1; SMN2GPR55NPC1RAB9A | |
| SCHEMBL2562918 | 0.56 | ALDH1A1 (0.51) | ALDH1A1GPR55VNN1NPC1RAB9A | |
| SCHEMBL2480308 | 0.54 | FDPS (0.53) | MAPK10 | |
| SCHEMBL450601 | 0.54 | MAPKAPK2 (0.46) | MAPK1ALDH1A1TSHRNR3C2VNN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6921762-B2 | Substituted indolizine-like compounds and methods of use | AMGEN INC. (US) | 2005-07-26 | — | — | US | disclosed |