Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 4/20 | 0.59 |
| ▸ | CTSK | P43235 | 4/20 | 0.59 |
| ▸ | CTSL | P07711 | 2/20 | 0.59 |
| ▸ | TACR1 | P25103 | 1/20 | 0.46 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.38 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6807070 | 0.81 | CMA1 (0.55) | — | |
| SCHEMBL29828325 | 0.80 | CTSS (0.63) | CTSSCTSKCTSLTACR1MMP2 | |
| SCHEMBL4899214 | 0.80 | CTSS (0.63) | CTSSCTSKCTSLTACR1MMP2 | |
| SCHEMBL999046 | 0.80 | CTSS (0.76) | CTSSCTSKCTSLTACR1MMP2 | |
| SCHEMBL29908025 | 0.80 | CTSS (0.76) | CTSSCTSKCTSLTACR1MMP2 | |
| SCHEMBL3599165 | 0.80 | CTSS (0.76) | CTSSCTSKCTSLTACR1MMP2 | |
| SCHEMBL999047 | 0.80 | CTSS (0.76) | CTSSCTSKCTSLTACR1MMP2 | |
| SCHEMBL29828648 | 0.80 | CTSS (0.76) | CTSSCTSKCTSLTACR1MMP2 | |
| SCHEMBL6855159 | 0.80 | CTSS (0.63) | CTSSCTSKCTSLTACR1MMP2 | |
| SCHEMBL4900597 | 0.80 | CTSS (0.63) | CTSSCTSKCTSLTACR1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6852744-B2 | Pyrrolidine derivatives and their use as chymase inhibitor | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 2005-02-08 | — | — | US | disclosed |
| US-20040102384-A1 | Pyrrolidine derivatives and their use as chymase inhibitor | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 2004-05-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040102384-A1 | Pyrrolidine derivatives and their use as chymase inhibitor | CMA1, CTRL, TPSD1 | CTSS 10/4885CTSK 42/4885CTSL 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.