Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 7/20 | 0.96 |
| ▸ | PKM | P14618 | 1/20 | 0.71 |
| ▸ | MEN1 | O00255 | 3/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.66 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.66 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.66 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 3/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2676273 | 0.87 | HPGD (0.79) | HPGDPKMMEN1KMT2ANPBWR1 | |
| SCHEMBL19088577 | 0.86 | HPGD (0.73) | HPGDMEN1KMT2ANPBWR1MCHR1 | |
| SCHEMBL5457332 | 0.85 | LRRK2 (0.79) | HPGDMEN1KMT2AALDH1A1LRRK2 | |
| SCHEMBL20516444 | 0.85 | HPGD (0.71) | HPGDPKMMEN1KMT2ANPBWR1 | |
| SCHEMBL14438968 | 0.85 | HPGD (0.71) | HPGDMEN1KMT2ANPBWR1MCHR1 | |
| SCHEMBL2091235 | 0.84 | HPGD (0.74) | HPGDPKMMEN1KMT2ANPBWR1 | |
| SCHEMBL15499084 | 0.84 | HPGD (0.75) | HPGDPKMMEN1KMT2ANPBWR1 | |
| SCHEMBL28355798 | 0.83 | HPGD (0.69) | HPGDPKMMEN1KMT2ANPBWR1 | |
| SCHEMBL19887433 | 0.83 | HPGD (0.69) | HPGDPKMMEN1KMT2ANPBWR1 | |
| SCHEMBL11293154 | 0.83 | HPGD (0.73) | HPGDPKMMEN1KMT2ANPBWR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230110003-A1 | PIPERIDINE DERIVATIVES AND COMPOSITIONS FOR THE INHIBITION OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) | Valo Health, LLC | 2023-04-13 | — | — | US | disclosed |
| US-11479564-B2 | Piperidine derivatives and compositions for the inhibition of nicotinamide phosphoribosyltransferase (NAMPT) | VALO HEALTH, INC. (US) | 2022-10-25 | — | — | US | disclosed |
| EP-1603564-A2 | USE OF PYRIDIN-2-YLMETHYLAMINE DERIVATIVES FOR THE PRODUCTION OF A MEDICAMENT FOR THE TREATMENT OF CHRONIC NEUROPATHOLOGICAL OR PSYCHOGENIC PAIN SYMPTOMS | PIERRE FABRE MEDICAMENT (FR) | 2005-12-14 | — | — | EP | disclosed |
| WO-2004083171-A2 | USE OF PYRIDIN-2-YLMETHYLAMINE DERIVATIVES FOR THE TREATMENT OF CHRONIC NEUROPATHOLOGICAL OR PSYCHOGENIC PAIN SYMPTOMS | PIERRE FABRE MEDICAMENT (FR) | 2004-09-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230110003-A1 | PIPERIDINE DERIVATIVES AND COMPOSITIONS FOR THE INHIBITION OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) | NAMPT, NAPRT, NNMT | HPGD 105/4885PKM 1229/4885MEN1 2895/4885 |
| US-11479564-B2 | Piperidine derivatives and compositions for the inhibition of nicotinamide phosphoribosyltransferase (NAMPT) | NAMPT, NAPRT, NNMT | HPGD 105/4885PKM 1229/4885MEN1 2895/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.