Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 3/20 | 0.54 |
| ▸ | CA2 | P00918 | 3/20 | 0.54 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA3 | P07451 | 1/20 | 0.50 |
| ▸ | TYR | P14679 | 1/20 | 0.50 |
| ▸ | DRD1 | P21728 | 1/20 | 0.50 |
| ▸ | CA4 | P22748 | 1/20 | 0.50 |
| ▸ | CA6 | P23280 | 1/20 | 0.50 |
| ▸ | CA5A | P35218 | 1/20 | 0.50 |
| ▸ | CA7 | P43166 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.50 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzoic Acid SCHEMBL1299820 | 0.91 | TSHR (0.64) | TSHRTP53ALDH1A1SMN1; SMN2CA1 | |
| Benzoic Acid SCHEMBL27295243 | 0.91 | TSHR (0.64) | TSHRTP53ALDH1A1SMN1; SMN2CA1 | |
| Terephthalic Acid SCHEMBL28383455 | 0.85 | TSHR (0.60) | TSHRTP53ALDH1A1SMN1; SMN2CA1 | |
| SCHEMBL28647699 | 0.85 | ALDH1A1 (0.75) | TSHRTP53ALDH1A1SMN1; SMN2CA1 | |
| Terephthalic Acid SCHEMBL10332533 | 0.84 | TSHR (0.75) | TSHRTP53ALDH1A1SMN1; SMN2CA1 | |
| SCHEMBL27721995 | 0.83 | CA12 (0.58) | ALDH1A1SMN1; SMN2CA1CA2TDP1 | |
| Isophthalic Acid SCHEMBL7178300 | 0.82 | HSD17B10 (0.55) | TSHRALDH1A1CA1CA2HSD17B10 | |
| Terephthalic Acid SCHEMBL1243625 | 0.81 | TSHR (0.80) | TSHRTP53ALDH1A1SMN1; SMN2CA1 | |
| SCHEMBL527251 | 0.79 | CA1 (0.54) | TSHRTP53ALDH1A1SMN1; SMN2CA1 | |
| Terephthalic Acid SCHEMBL31728631 | 0.79 | TSHR (0.67) | TSHRTP53ALDH1A1SMN1; SMN2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1878798-A | Curable polymer compound | SHOWA DENKO KK (JP) | 2006-12-13 | — | — | CN | disclosed |
| US-6936392-B2 | Developing agent | KABUSHIKI KAISHA TOSHIBA (JP) | 2005-08-30 | — | — | US | disclosed |
| US-20040137351-A1 | Developing agent | TOSHIBA TEC KABUSHIKI KAISHA | 2004-07-15 | — | — | US | disclosed |