Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.55 |
| ▸ | RAB9A | P51151 | 6/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | LGALS8 | O00214 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11856795 | 0.76 | NPC1 (0.58) | NPC1RAB9ASMN1; SMN2LMNATDP1 | |
| SCHEMBL7759274 | 0.76 | NPC1 (0.50) | NPC1RAB9ASMN1; SMN2LMNATDP1 | |
| SCHEMBL7586423 | 0.76 | NPC1 (0.55) | NPC1RAB9ASMN1; SMN2LMNATDP1 | |
| SCHEMBL29735170 | 0.75 | NPC1 (0.57) | NPC1RAB9ASMN1; SMN2LMNATDP1 | |
| SCHEMBL10940866 | 0.75 | NPC1 (0.57) | NPC1RAB9ASMN1; SMN2LMNATDP1 | |
| SCHEMBL6216387 | 0.73 | NPC1 (0.64) | NPC1RAB9ASMN1; SMN2LMNATDP1 | |
| SCHEMBL9870217 | 0.72 | NPC1 (0.62) | NPC1RAB9ASMN1; SMN2LMNATDP1 | |
| SCHEMBL13799918 | 0.72 | RAB9A (0.58) | NPC1RAB9ASMN1; SMN2TDP1PKM | |
| SCHEMBL29703247 | 0.72 | TDP1 (0.72) | NPC1RAB9ASMN1; SMN2LMNATDP1 | |
| SCHEMBL9027681 | 0.72 | TDP1 (0.72) | NPC1RAB9ASMN1; SMN2LMNATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6903098-B1 | Use of phthalazine derivatives | ABBOTT GMBH & CO. (DE) | 2005-06-07 | — | — | US | disclosed |
| EP-1231982-A2 | USE OF PHTHALAZINE DERIVATIVES | BASF AKTIENGESELLSCHAFT (DE) | 2002-08-21 | — | — | EP | disclosed |
| WO-2001082877-A2 | USE OF PARP INHIBITORS IN COSMETIC PREPARATIONS | BASF AKTIENGESELLSCHAFT (DE) | 2001-11-08 | — | — | WO | disclosed |
| WO-2000067734-A2 | USE OF PHTHALAZINE DERIVATIVES | BASF AKTIENGESELLSCHAFT (DE) | 2000-11-16 | — | — | WO | disclosed |