Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 4/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5497575 | 0.82 | PTGDR2 (0.74) | PTGDR2GFERNPSR1MEN1KMT2A | |
| SCHEMBL27641688 | 0.81 | MAPT (0.55) | PTGDR2GFERNPSR1GAAMAPK1 | |
| SCHEMBL6276664 | 0.78 | PTGDR2 (0.53) | PTGDR2GFERNPSR1CNR2GAA | |
| SCHEMBL6274568 | 0.75 | PTGDR2 (0.54) | PTGDR2GFERNPSR1ALDH1A1TSHR | |
| SCHEMBL15544298 | 0.73 | CNR2 (0.52) | NPSR1CNR2HSD11B1MEN1ALDH1A1 | |
| SCHEMBL4133008 | 0.72 | PTGDR2 (0.68) | PTGDR2MEN1KMT2ATSHRHTT | |
| SCHEMBL5504734 | 0.71 | PTGDR2 (0.58) | PTGDR2NPSR1MEN1KMT2AHTT | |
| SCHEMBL5444441 | 0.71 | PTGDR2 (0.52) | PTGDR2GFERNPSR1MAPK1MEN1 | |
| SCHEMBL15544590 | 0.70 | NOTUM (0.60) | NPSR1CNR2HSD11B1MEN1ALDH1A1 | |
| SCHEMBL5513344 | 0.70 | PTGDR2 (0.56) | PTGDR2NPSR1MEN1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1556047-A2 | PGD2 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2005-07-27 | — | — | EP | claimed |
| WO-2004032848-A2 | PGD2 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2004-04-22 | — | — | WO | claimed |