Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 4/20 | 0.50 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL89156 | 1.00 | PDE4B (0.50) | PDE4BNR1H2USP2SMN1; SMN2EPHX1 | |
| SCHEMBL5008891 | 1.00 | PDE4B (0.50) | PDE4BNR1H2USP2SMN1; SMN2EPHX1 | |
| SCHEMBL16667444 | 1.00 | PDE4B (0.50) | PDE4BNR1H2USP2SMN1; SMN2EPHX1 | |
| SCHEMBL89513 | 0.94 | PDE4B (0.54) | PDE4BNR1H2USP2SMN1; SMN2EPHX1 | |
| SCHEMBL8301285 | 0.89 | PDE4B (0.53) | PDE4BNR1H2USP2SMN1; SMN2EPHX1 | |
| SCHEMBL8268416 | 0.89 | PDE4B (0.53) | PDE4BNR1H2USP2SMN1; SMN2EPHX1 | |
| SCHEMBL1759697 | 0.89 | PDE4B (0.53) | PDE4BNR1H2USP2SMN1; SMN2EPHX1 | |
| SCHEMBL13595122 | 0.89 | PDE4B (0.53) | PDE4BNR1H2USP2SMN1; SMN2EPHX1 | |
| SCHEMBL22160615 | 0.89 | PDE4B (0.53) | PDE4BNR1H2USP2SMN1; SMN2EPHX1 | |
| SCHEMBL3647203 | 0.87 | PDE4B (0.49) | PDE4BNR1H2USP2SMN1; SMN2EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2420491-B1 | 3 , 5-SUBSTITUED PIPERIDINE COMPOUNDS AS RENIN INHIBITORS | NOVARTIS AG (CH) | 2013-07-03 | — | — | EP | disclosed |
| EP-2420491-A1 | 3 , 5-substitued piperidine compounds as renin inhibitors | Novartis AG (CH) | 2012-02-22 | — | — | EP | disclosed |