Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NNMT | P40261 | 7/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HPGDS | O60760 | 1/20 | 0.38 |
| ▸ | PRKCI | P41743 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.36 |
| ▸ | STAMBP | O95630 | 1/20 | 0.36 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.35 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30427718 | 1.00 | NNMT (0.51) | NNMTTSHRPARP1SMN1; SMN2HPGDS | |
| SCHEMBL25787753 | 0.92 | NNMT (0.52) | NNMTTSHRSMN1; SMN2HPGDSPRKCI | |
| SCHEMBL10650921 | 0.86 | MGAM (0.41) | NNMTPSMD14LMNA | |
| SCHEMBL31003073 | 0.85 | NNMT (0.36) | NNMTSMN1; SMN2PRKCICYP11B2 | |
| SCHEMBL25789750 | 0.81 | MAPK1 (0.41) | SMN1; SMN2PSMD14CYP11B2LMNA | |
| SCHEMBL25787974 | 0.79 | TSHR (0.54) | NNMTTSHRSMN1; SMN2HPGDSPIK3CA | |
| SCHEMBL17371695 | 0.77 | GRM1 (0.44) | NNMTSMN1; SMN2 | |
| SCHEMBL4481718 | 0.76 | NNMT (0.49) | NNMTTSHRSMN1; SMN2HPGDSPSMD14 | |
| SCHEMBL16495711 | 0.73 | NNMT (0.56) | NNMTSMN1; SMN2HPGDSPSMD14STAMBP | |
| SCHEMBL29664524 | 0.72 | NPC1 (0.43) | NNMTTSHRSMN1; SMN2HPGDSCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6878705-B2 | 4-oxo-4,7-dihydrofuro[2,3-b]pyridine-5-carboxamide antiviral agents | PFIZER (US) | 2005-04-12 | — | — | US | claimed |
| WO-2023129512-A1 | BICYCLIC INHIBITORS OF NICOTINAMIDE N-METHYLTRANSFERASE, COMPOSITIONS AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2023-07-06 | — | — | WO | disclosed |