Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6284852 | 0.89 | TNF (0.33) | TNFMAPK14 | |
| SCHEMBL6283654 | 0.88 | MAPK14 (0.33) | TNFMAPK14 | |
| SCHEMBL6699719 | 0.79 | MAPK14 (0.40) | TNFMAPK14 | |
| SCHEMBL6283072 | 0.78 | MAPK14 (0.37) | TNFMAPK14SMN1; SMN2 | |
| SCHEMBL5987486 | 0.77 | TNF (0.34) | TNFMAPK14SMN1; SMN2 | |
| SCHEMBL5995957 | 0.74 | MAPK14 (0.38) | TNFMAPK14 | |
| SCHEMBL6276867 | 0.72 | MAPK14 (0.38) | TNFMAPK14 | |
| SCHEMBL6270980 | 0.69 | MAPK14 (0.35) | TNFMAPK14 | |
| SCHEMBL6689156 | 0.68 | ABL1 (0.60) | TNFMAPK14 | |
| SCHEMBL5998813 | 0.68 | MAPK14 (0.34) | TNFMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1530477-A1 | COMBINATION THERAPY WITH p38 MAP KINASE INHIBITORS AND THEIR PHARMACEUTICAL COMPOSITIONS | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2005-05-18 | — | — | EP | disclosed |
| WO-2004014387-A1 | COMBINATION THERAPY WITH p38 MAP KINASE INHIBITORS AND THEIR PHARMACEUTICAL COMPOSITIONS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2004-02-19 | — | — | WO | disclosed |