Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 3/20 | 0.33 |
| ▸ | TNF | P01375 | 1/20 | 0.33 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.32 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.31 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.31 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.31 |
| ▸ | BRAF | P15056 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6284852 | 0.94 | TNF (0.33) | MAPK14TNFMAPK12 | |
| SCHEMBL6447028 | 0.90 | TNF (0.33) | MAPK14TNF | |
| SCHEMBL6283622 | 0.88 | TNF (0.34) | MAPK14TNF | |
| SCHEMBL6283072 | 0.80 | MAPK14 (0.37) | MAPK14TNFMAPK12 | |
| SCHEMBL6699719 | 0.79 | MAPK14 (0.40) | MAPK14TNFMAPK12MAPK13MAPK11 | |
| SCHEMBL5989027 | 0.76 | MAPK14 (0.33) | MAPK14TNFMAPK12MAPK13MAPK11 | |
| SCHEMBL5995957 | 0.72 | MAPK14 (0.38) | MAPK14TNFMAPK12MAPK13MAPK11 | |
| SCHEMBL6270980 | 0.72 | MAPK14 (0.35) | MAPK14TNFMAPK12MAPK13MAPK11 | |
| SCHEMBL5998813 | 0.71 | MAPK14 (0.34) | MAPK14TNFMAPK12MAPK13MAPK11 | |
| SCHEMBL6276867 | 0.70 | MAPK14 (0.38) | MAPK14TNFMAPK12MAPK13MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1530477-A1 | COMBINATION THERAPY WITH p38 MAP KINASE INHIBITORS AND THEIR PHARMACEUTICAL COMPOSITIONS | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2005-05-18 | — | — | EP | disclosed |
| WO-2004014387-A1 | COMBINATION THERAPY WITH p38 MAP KINASE INHIBITORS AND THEIR PHARMACEUTICAL COMPOSITIONS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2004-02-19 | — | — | WO | disclosed |