Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.59 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | KCNK3 | O14649 | 6/20 | 0.48 |
| ▸ | KCNK9 | Q9NPC2 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | ELANE | P08246 | 1/20 | 0.48 |
| ▸ | SNCA | P37840 | 2/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6276176 | 0.86 | KDR (0.55) | KDRFGFR1MAPTKMT2AMEN1 | |
| SCHEMBL5250366 | 0.74 | KDR (1.00) | KDRFGFR1 | |
| SCHEMBL5250363 | 0.74 | KDR (1.00) | KDRFGFR1 | |
| SCHEMBL6496546 | 0.74 | KDR (0.53) | KDRFGFR1MAPTKCNK3KCNK9 | |
| SCHEMBL4249753 | 0.69 | KCNK3 (0.92) | CYP1A2CYP3A4GAAMAPTCYP2C9 | |
| SCHEMBL5879266 | 0.68 | KDR (0.68) | KDRFGFR1ELANESNCA | |
| SCHEMBL5252223 | 0.68 | KDR (0.68) | KDRFGFR1ELANESNCA | |
| SCHEMBL30608967 | 0.68 | KCNK3 (0.87) | MAPTKCNK3KCNK9KMT2AMEN1 | |
| SCHEMBL259666 | 0.68 | KCNK3 (0.87) | MAPTKCNK3KCNK9KMT2AMEN1 | |
| SCHEMBL23367931 | 0.68 | CYP1A2 (0.78) | CYP1A2CYP3A4GAAMAPTCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6891044-B2 | Indazole compounds and pharmaceutical compositions for Inhibiting protein kinases, and methods for their use | AGOURON PHARMACEUTICALS, INC. (US) | 2005-05-10 | — | — | US | disclosed |