Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 6/20 | 0.53 |
| ▸ | SNCA | P37840 | 2/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.49 |
| ▸ | KCNK3 | O14649 | 6/20 | 0.49 |
| ▸ | KCNK9 | Q9NPC2 | 4/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22543054 | 0.75 | SNCA (0.83) | SNCAKCNK3KCNK9PKMSIRT1 | |
| SCHEMBL6283770 | 0.74 | KDR (0.59) | KDRSNCAFGFR1KCNK3KCNK9 | |
| SCHEMBL5249531 | 0.70 | KDR (0.53) | KDRSNCAFGFR1KCNK3KCNK9 | |
| SCHEMBL2298254 | 0.70 | KCNK3 (1.00) | KCNK3KCNK9SIRT1ALDH1A1MAPT | |
| SCHEMBL5249980 | 0.69 | KDR (1.00) | KDRFGFR1 | |
| SCHEMBL5249981 | 0.69 | KDR (1.00) | KDRFGFR1 | |
| SCHEMBL6276176 | 0.69 | KDR (0.55) | KDRSNCAFGFR1MAPTMEN1 | |
| SCHEMBL22543018 | 0.68 | PKM (0.72) | SNCAKCNK3KCNK9PKMSIRT1 | |
| SCHEMBL5247768 | 0.67 | KDR (1.00) | KDRFGFR1 | |
| SCHEMBL5247760 | 0.67 | KDR (1.00) | KDRFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6884890-B2 | Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use | AGOURON PHARMACEUTICALS, INC. (US) | 2005-04-26 | — | — | US | disclosed |