Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.62 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.62 |
| ▸ | CDC25A | P30304 | 6/20 | 0.61 |
| ▸ | CES1 | P23141 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6286098 | 0.99 | CDC25A (0.63) | ALDH1A1ALDH2ALDH3A1CDC25ACES1 | |
| SCHEMBL6281435 | 0.99 | CDC25A (0.63) | ALDH1A1ALDH2ALDH3A1CDC25ACES1 | |
| SCHEMBL6283021 | 0.99 | CDC25A (0.63) | ALDH1A1ALDH2ALDH3A1CDC25ACES1 | |
| SCHEMBL6280422 | 0.99 | CDC25A (0.63) | ALDH1A1ALDH2ALDH3A1CDC25ACES1 | |
| SCHEMBL6279195 | 0.99 | CDC25A (0.63) | ALDH1A1ALDH2ALDH3A1CDC25ACES1 | |
| SCHEMBL6284050 | 0.99 | CDC25A (0.63) | ALDH1A1ALDH2ALDH3A1CDC25ACES1 | |
| SCHEMBL6286569 | 0.99 | CDC25A (0.63) | ALDH1A1ALDH2ALDH3A1CDC25ACES1 | |
| SCHEMBL6283990 | 0.96 | ALDH1A1 (0.56) | ALDH1A1ALDH2ALDH3A1CDC25ACES1 | |
| SCHEMBL5424141 | 0.88 | ALDH1A1 (0.55) | ALDH1A1ALDH2ALDH3A1CDC25ACES1 | |
| SCHEMBL6283127 | 0.86 | ALDH1A1 (0.49) | ALDH1A1ALDH2ALDH3A1CDC25ACES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6906090-B1 | Compositions and methods for treating mycobacterial diseases | ASTRAZENECA AB (SE) | 2005-06-14 | — | — | US | claimed |
| EP-1058548-B1 | THE USE OF ISATIN AND OXINDOLE DERIVATIVES IN THE PREPARATION OF A MEDICAMENT FOR USE IN THE TREATMENT OF MYCOBACTERIAL DISEASE | ASTRAZENECA AB (SE) | 2003-09-17 | — | — | EP | claimed |
| EP-1058548-A1 | NEW USE | AstraZeneca AB (SE) | 2000-12-13 | — | — | EP | claimed |
| WO-1999044608-A1 | NEW USE | ASTRAZENECA AB (SE) | 1999-09-10 | — | — | WO | claimed |
| US-6906090-B1 | Compositions and methods for treating mycobacterial diseases | ASTRAZENECA AB (SE) | 2005-06-14 | — | — | US | disclosed |
| EP-1058548-B1 | THE USE OF ISATIN AND OXINDOLE DERIVATIVES IN THE PREPARATION OF A MEDICAMENT FOR USE IN THE TREATMENT OF MYCOBACTERIAL DISEASE | ASTRAZENECA AB (SE) | 2003-09-17 | — | — | EP | disclosed |
| EP-1058548-A1 | NEW USE | AstraZeneca AB (SE) | 2000-12-13 | — | — | EP | disclosed |
| WO-1999044608-A1 | NEW USE | ASTRAZENECA AB (SE) | 1999-09-10 | — | — | WO | disclosed |