Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 1/20 | 0.39 |
| ▸ | FNTB | P49356 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | LTB4R2 | Q9NPC1 | 3/20 | 0.35 |
| ▸ | TACR1 | P25103 | 2/20 | 0.35 |
| ▸ | LTA4H | P09960 | 2/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.34 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL628800 | 0.90 | FNTA (0.37) | FNTAFNTBKMT2AMEN1ATM | |
| SCHEMBL6624997 | 0.83 | FNTA (0.52) | FNTAFNTB | |
| SCHEMBL628432 | 0.83 | FNTA (0.62) | FNTAFNTB | |
| SCHEMBL628445 | 0.79 | FNTA (0.37) | FNTAFNTBLTB4R2 | |
| SCHEMBL628444 | 0.76 | NPSR1 (0.40) | KMT2AMEN1 | |
| SCHEMBL629820 | 0.74 | FNTA (0.42) | FNTAFNTBLTB4R2TACR1 | |
| SCHEMBL628888 | 0.72 | FNTA (0.51) | FNTAFNTBLTB4R2 | |
| SCHEMBL7871149 | 0.72 | BRS3 (0.46) | FNTAFNTBKMT2AMEN1LTB4R2 | |
| SCHEMBL629682 | 0.70 | FNTA (0.69) | FNTAFNTBLTB4R2 | |
| SCHEMBL628802 | 0.70 | FNTA (0.36) | FNTAFNTBKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0986384-B1 | INHIBITORS OF PROTEIN ISOPRENYL TRANSFERASES | UNIV PITTSBURGH (US) | 2012-02-22 | — | — | EP | disclosed |
| US-6310095-B1 | INHIBITING OR TREATING CANCER, TREATING INTIMAL HYPERPLASIA ASSOCIATED WITH RESTENOSIS AND ATHEROSCLEROSIS, INHIBITING POST-TRANSLATIONAL MODIFICATION OF ONCOGENIC RAS PROTEIN BY PROTEIN FARNESYLTRANSFERASE AND/OR GERANYLGERANYLTRANSFERASE | UNIVERSITY OF PITTSBURGH | 2001-10-30 | — | — | US | disclosed |