Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.39 |
| ▸ | GNAO1 | P09471 | 6/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.37 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.37 |
| ▸ | GNAI3 | P08754 | 5/20 | 0.37 |
| ▸ | GNAI1 | P63096 | 5/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | SOD3 | P08294 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5770282 | 0.98 | TAAR1 (0.42) | TAAR1CYP2D6SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL881080 | 0.86 | SLC6A2 (0.40) | TAAR1CYP2D6SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8553122 | 0.84 | RAD52 (0.35) | TAAR1CYP2D6SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL27911335 | 0.84 | TAAR1 (0.54) | TAAR1CYP2D6SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8555780 | 0.82 | RAD52 (0.35) | TAAR1 | |
| Hydrazine SCHEMBL8554894 | 0.82 | RAD52 (0.35) | TAAR1 | |
| SCHEMBL4446755 | 0.82 | TAAR1 (0.53) | TAAR1CYP2D6SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL250854 | 0.82 | TAAR1 (0.53) | TAAR1CYP2D6SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8560784 | 0.82 | RAD52 (0.35) | TAAR1 | |
| SCHEMBL6363695 | 0.81 | TAAR1 (0.35) | TAAR1CYP2D6SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102977092-A | Application of aromatic alkanoyl tetrahydro-beta-carboline and derivative thereof in treatment of cancer | UNIV EAST CHINA NORMAL | 2013-03-20 | — | — | CN | claimed |
| CN-102977091-A | Application of aromatic alkanoyl tetrahydro-beta-carboline and derivative thereof in treatment of metabolic disease | UNIV EAST CHINA NORMAL | 2013-03-20 | — | — | CN | claimed |
| CN-114686187-B | Hairbrush-shaped amide lubricant and preparation method and application thereof | 中石化石油工程技术服务有限公司 | 2023-07-21 | — | — | CN | disclosed |
| EP-2805956-B1 | GAMBOGENIC ACID DERIVATIVES, PREPARATION METHOD AND APPLICATION THEREOF | NINTH PEOPLES HOSPITAL SCHOOL MEDICINE SHANGHAI JIAO TONG UNIV (CN) | 2018-12-26 | — | — | EP | disclosed |
| CN-102977091-B | Fragrance alkyloyl tetrahydro-beta-carboline and the application of derivative in treatment metabolic disease thereof | EAST CHINA NORMAL UNIVERSITY (CN) | 2016-03-09 | — | — | CN | disclosed |
| CN-102977092-B | Fragrance alkyloyl tetrahydro-beta-carboline and the application of derivative in treatment malignant tumour thereof | EAST CHINA NORMAL UNIVERSITY (CN) | 2016-02-24 | — | — | CN | disclosed |
| US-9187491-B2 | Gambogenic acid derivatives, preparation method and application thereof | NINTH PEOPLE'S HOSPITAL, SCHOOL MEDICINE SHANGHAI JIAO TONG UNIVERSITY (CN) | 2015-11-17 | — | — | US | disclosed |
| CN-102558193-B | Gambogenic acid derivatives, and preparation method and application thereof | JIAOTONG 9TH PEOPLES HOSPITAL | 2014-12-17 | — | — | CN | disclosed |
| EP-2805956-A1 | GAMBOGENIC ACID DERIVATIVES, PREPARATION METHOD AND APPLICATION THEREOF | Ninth People's Hospital, School Medicine Shanghai Jiao Tong University (CN) | 2014-11-26 | — | — | EP | disclosed |
| US-20140309418-A1 | Gambogenic Acid Derivatives, Preparation Method and Application Thereof | NINTH PEOPLE'S HOSPITAL, SCHOOL MEDICINE SHANGHAI JIAO TONG UNIVERSITY (CN) | 2014-10-16 | — | — | US | disclosed |
| CN-102977091-A | Application of aromatic alkanoyl tetrahydro-beta-carboline and derivative thereof in treatment of metabolic disease | UNIV EAST CHINA NORMAL | 2013-03-20 | — | — | CN | disclosed |
| CN-102977092-A | Application of aromatic alkanoyl tetrahydro-beta-carboline and derivative thereof in treatment of cancer | UNIV EAST CHINA NORMAL | 2013-03-20 | — | — | CN | disclosed |
| CN-1715283-A | Neogambogic acid derivative and its production and use | SHANGHAI INST OF MATERIAL MEDI (CN) | 2006-01-04 | — | — | CN | disclosed |
| JP-2005120014-A | METHOD FOR PRODUCING ARYLMETHYLPIPERAZINE DERIVATIVE | TORAY FINE CHEMICALS CO LTD | 2005-05-12 | — | — | JP | disclosed |
| EP-0546583-B1 | Piperazinyl-and piperidinyl-cyclohexanols | BRISTOL MYERS SQUIBB CO (US) | 1996-05-22 | — | — | EP | disclosed |
| EP-0546583-A1 | Piperazinyl-and piperidinyl-cyclohexanols | Bristol-Myers Squibb Company (US) | 1993-06-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140309418-A1 | Gambogenic Acid Derivatives, Preparation Method and Application Thereof | GYS2, GYPA, GLS2 | TAAR1 2357/4885CYP2D6 749/4885SLC6A2 3715/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.