Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | SCN4A | P35499 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.47 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.47 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7422735 | 1.00 | SMN1; SMN2 (0.60) | SMN1; SMN2NPC1LMNANPSR1HSD17B10 | |
| SCHEMBL12057492 | 1.00 | SMN1; SMN2 (0.60) | SMN1; SMN2NPC1LMNANPSR1HSD17B10 | |
| SCHEMBL8908114 | 0.92 | SMN1; SMN2 (0.51) | SMN1; SMN2NPC1LMNANPSR1HSD17B10 | |
| SCHEMBL15307926 | 0.88 | SMN1; SMN2 (0.60) | SMN1; SMN2NPC1LMNANPSR1HSD17B10 | |
| SCHEMBL2848716 | 0.88 | SMN1; SMN2 (0.60) | SMN1; SMN2NPC1LMNANPSR1HSD17B10 | |
| SCHEMBL5403510 | 0.88 | SMN1; SMN2 (0.60) | SMN1; SMN2NPC1LMNANPSR1HSD17B10 | |
| SCHEMBL27366305 | 0.87 | SMN1; SMN2 (0.59) | SMN1; SMN2NPC1LMNANPSR1HSD17B10 | |
| SCHEMBL8237595 | 0.86 | SMN1; SMN2 (0.58) | SMN1; SMN2NPC1LMNANPSR1HSD17B10 | |
| SCHEMBL13114591 | 0.86 | SMN1; SMN2 (0.58) | SMN1; SMN2NPC1LMNANPSR1HSD17B10 | |
| SCHEMBL6466465 | 0.86 | SMN1; SMN2 (0.58) | SMN1; SMN2NPC1LMNANPSR1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6900238-B1 | HIV protease inhibitors | THE SCRIPPS RESEARCH INSTITUTE (US) | 2005-05-31 | — | — | US | disclosed |
| EP-0873519-A4 | HIV PROTEASE INHIBITORS | SCRIPPS RESEARCH INST (US) | 2005-04-27 | — | — | EP | disclosed |
| EP-0873519-A1 | HIV PROTEASE INHIBITORS | The Scripps Research Institute (US) | 1998-10-28 | — | — | EP | disclosed |
| WO-1997021100-A9 | HIV PROTEASE INHIBITORS | — | 1997-10-30 | — | — | WO | disclosed |
| WO-1997021100-A1 | HIV PROTEASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 1997-06-12 | — | — | WO | disclosed |
| US-5629406-A | AMINO ACID DERIVATIVES | SANKYO COMPANY, LIMITED (JP) | 1997-05-13 | — | — | US | disclosed |
| CN-1091432-A | Can suppress the active peptide of hiv protease, its preparation with and medical use | SANKYO CO (JP) | 1994-08-31 | — | — | CN | disclosed |
| WO-1993013066-A1 | CYCLIC AMIDES OF 3-AMINO-2-HYDROXY-CARBOXYLIC ACIDS AS HIV-PROTEASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1993-07-08 | — | — | WO | disclosed |