Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 2/20 | 0.45 |
| ▸ | NOS2 | P35228 | 2/20 | 0.45 |
| ▸ | MBOAT4 | Q96T53 | 16/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6050317 | 0.81 | NOS2 (0.64) | SLC6A4NOS2MBOAT4GPR119 | |
| SCHEMBL6050389 | 0.80 | SLC6A4 (0.52) | SLC6A4NOS2MBOAT4GPR119 | |
| SCHEMBL6050571 | 0.79 | SLC6A4 (0.51) | SLC6A4NOS2MBOAT4GPR119 | |
| SCHEMBL2532315 | 0.78 | SLC6A4 (0.49) | SLC6A4NOS2GPR119CYP3A4AAK1 | |
| SCHEMBL6280985 | 0.76 | SLC6A4 (0.49) | SLC6A4NOS2MBOAT4GPR119CYP3A4 | |
| SCHEMBL6286190 | 0.74 | SLC6A4 (0.62) | SLC6A4NOS2MBOAT4GPR119CYP3A4 | |
| SCHEMBL2528648 | 0.73 | SLC6A4 (0.46) | SLC6A4NOS2MBOAT4GPR119 | |
| SCHEMBL2528769 | 0.73 | GAA (0.50) | SLC6A4NOS2MBOAT4GPR119 | |
| SCHEMBL2528904 | 0.72 | SLC6A4 (0.46) | SLC6A4NOS2MBOAT4GPR119 | |
| SCHEMBL6646715 | 0.72 | SLC6A4 (0.44) | SLC6A4NOS2MBOAT4GPR119CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2005501834-A | — | — | 2005-01-20 | — | — | JP | claimed |
| EP-1414802-A1 | HETEROARYLHETEROALKYLAMINE DERIVATIVES AND THEIR USE AS INHIBITORS OF NITRIC OXIDE SYNTHASE | AstraZeneca AB (SE) | 2004-05-06 | — | — | EP | claimed |
| WO-2003011830-A1 | HETEROARYLHETEROALKYLAMINE DERIVATIVES AND THEIR USE AS INHIBITORS OF NITRIC OXIDE SYNTHASE | ASTRAZENECA AB (SE) | 2003-02-13 | — | — | WO | claimed |
| EP-1414802-A1 | HETEROARYLHETEROALKYLAMINE DERIVATIVES AND THEIR USE AS INHIBITORS OF NITRIC OXIDE SYNTHASE | AstraZeneca AB (SE) | 2004-05-06 | — | — | EP | disclosed |
| WO-2003011830-A1 | HETEROARYLHETEROALKYLAMINE DERIVATIVES AND THEIR USE AS INHIBITORS OF NITRIC OXIDE SYNTHASE | ASTRAZENECA AB (SE) | 2003-02-13 | — | — | WO | disclosed |