Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 1.00 |
| ▸ | LCK | P06239 | 2/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | APEX1 | P27695 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6285724 | 1.00 | EGFR (1.00) | EGFRLCKKDM4ECYP1A2MAPT | |
| SCHEMBL6285718 | 1.00 | EGFR (1.00) | EGFRLCKKDM4ECYP1A2MAPT | |
| SCHEMBL8749032 | 0.85 | EGFR (1.00) | EGFRLCKKDM4EMEN1KMT2A | |
| SCHEMBL8743707 | 0.85 | EGFR (1.00) | EGFRLCKKDM4EMEN1KMT2A | |
| SCHEMBL8830586 | 0.79 | EGFR (0.66) | EGFRLCKKDM4ECYP1A2MAPT | |
| SCHEMBL8830416 | 0.79 | EGFR (0.66) | EGFRLCKKDM4ECYP1A2MAPT | |
| SCHEMBL9539321 | 0.76 | KDM4E (0.71) | EGFRLCKKDM4ECYP1A2MAPT | |
| SCHEMBL9539318 | 0.76 | KDM4E (0.71) | EGFRLCKKDM4ECYP1A2MAPT | |
| SCHEMBL7456830 | 0.76 | EGFR (0.60) | EGFRLCKKDM4ECYP1A2MAPT | |
| SCHEMBL7456833 | 0.76 | EGFR (0.60) | EGFRLCKKDM4ECYP1A2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE38761-E1 | Styryl compounds which inhibit EGF receptor protein tyrosine kinase | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 2005-07-19 | — | — | US | disclosed |
| EP-0788358-B1 | USE OF PYRAZOLE COMPOUNDS FOR THE TREATMENT OF GLOMERULONEPHRITIS, CANCER, ATHEROSCLEROSIS OR RESTENOSIS | MILLENNIUM PHARM INC (US) | 2004-03-31 | — | — | EP | disclosed |
| EP-0788356-B9 | METHOD AND COMPOSITIONS FOR INHIBITING PROTEIN KINASES | COR THERAPEUTICS INC (US) | 2002-10-02 | — | — | EP | disclosed |
| EP-0788356-B1 | METHOD AND COMPOSITIONS FOR INHIBITING PROTEIN KINASES | COR THERAPEUTICS INC (US) | 2001-12-12 | — | — | EP | disclosed |
| US-5916908-A | Pharmaceutical pyrazole compositions useful as inhibitors of protein kinases | COR THERAPEUTICS, INC. (US) | 1999-06-29 | — | — | US | disclosed |
| US-5795910-A | Method and compositions for inhibiting protein kinases | COR THERAPEUTICS, INC. (US) | 1998-08-18 | — | — | US | disclosed |
| US-5728726-A | Method and compositions for inhibiting protein kinases | COR THERAPEUTICS, INC. (US) | 1998-03-17 | — | — | US | disclosed |
| US-5674892-A | CONTACTING WITH BENZOXACYCLOTETRADECIN DERIVATIVES | COR THERAPEUTICS, INC. (US) | 1997-10-07 | — | — | US | disclosed |
| EP-0788358-A2 | PHARMACEUTICAL PYRAZOLE COMPOSITIONS USEFUL AS INHIBITORS OF PROTEIN KINASES | COR THERAPEUTICS, INC. (US) | 1997-08-13 | — | — | EP | disclosed |
| EP-0788356-A2 | METHOD AND COMPOSITIONS FOR INHIBITING PROTEIN KINASES | COR THERAPEUTICS, INC. (US) | 1997-08-13 | — | — | EP | disclosed |
| WO-1996014843-A2 | PHARMACEUTICAL PYRAZOLE COMPOSITIONS USEFUL AS INHIBITORS OF PROTEIN KINASES | COR THERAPEUTICS, INC. (US) | 1996-05-23 | — | — | WO | disclosed |
| WO-1996013259-A2 | METHOD AND COMPOSITIONS FOR INHIBITING PROTEIN KINASES | COR THERAPEUTICS, INC. (US) | 1996-05-09 | — | — | WO | disclosed |
| US-5217999-A | Antigrowth agents | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 1993-06-08 | — | — | US | disclosed |
| WO-1991016892-A1 | STYRYL COMPOUNDS WHICH INHIBIT EGF RECEPTOR PROTEIN TYROSINE KINASE | RORER INTERNATIONAL (HOLDINGS), INC. (US) | 1991-11-14 | — | — | WO | disclosed |