SCHEMBL8743707

SCHEMBL8743707

N#CC(=Cc1cc(O)ccc1O)C(=O)O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
EGFR P00533 5/20 1.00
LCK P06239 1/20 0.74
KDM4E B2RXH2 3/20 0.60
CISD1 Q9NZ45 1/20 0.60
SLC16A3 O15427 1/20 0.60
ALDH1A1 P00352 1/20 0.60
CYP3A4 P08684 1/20 0.60
HPGD P15428 1/20 0.60
SLC16A1 P53985 1/20 0.60
GPR35 Q9HC97 1/20 0.60
MIF P14174 1/20 0.50
KMT2A Q03164 2/20 0.48
LMNA P02545 1/20 0.48
PKM P14618 1/20 0.48
MEN1 O00255 1/20 0.43
GAA P10253 1/20 0.43
NPSR1 Q6W5P4 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8749032 1.00 EGFR (1.00) EGFRLCKKDM4ECISD1SLC16A3
SCHEMBL21457392 0.88 EGFR (0.79) EGFRLCKKDM4ECISD1SLC16A3
SCHEMBL21457390 0.88 EGFR (0.79) EGFRLCKKDM4ECISD1SLC16A3
SCHEMBL6285718 0.85 EGFR (1.00) EGFRLCKKDM4EALDH1A1CYP3A4
SCHEMBL6285724 0.85 EGFR (1.00) EGFRLCKKDM4EALDH1A1CYP3A4
SCHEMBL6285728 0.85 EGFR (1.00) EGFRLCKKDM4EALDH1A1CYP3A4
SCHEMBL15988462 0.81 EGFR (0.68) EGFRLCKKDM4ECISD1SLC16A3
SCHEMBL10560029 0.81 EGFR (0.68) EGFRLCKKDM4ECISD1SLC16A3
SCHEMBL2058767 0.79 EGFR (0.66) EGFRLCKKDM4ECISD1SLC16A3
SCHEMBL393439 0.79 EGFR (0.66) EGFRLCKKDM4ECISD1SLC16A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0403238-A2 Cosmetic composition UNILEVER PLC (GB) 1990-12-19 EP claimed
EP-0571198-B1 Cosmetic composition containing hair-growth promoter UNILEVER PLC (GB) 1997-03-19 EP disclosed
EP-0750498-A1 USE OF ANTAGONISTS OF EGF OR TGF-ALPHA FOR THE TREATMENT AND PROPHYLAXIS OF ACNE UNILEVER PLC (GB) 1997-01-02 EP disclosed
EP-0572167-B1 Cosmetic composition UNILEVER PLC (GB) 1996-10-09 EP disclosed
US-5559092-A HAIR GROWTH, GLUTAMINE DIPEPTIDE CHESEBROUGH-POND'S USA CO. DIVISION OF CONOPCO, INC. (US) 1996-09-24 US disclosed
EP-0490581-B1 Cosmetic composition UNILEVER PLC (GB) 1996-05-22 EP disclosed
EP-0517371-B1 Hair growth composition containing citric acid esters UNILEVER PLC (GB) 1996-01-10 EP disclosed
WO-1995024896-A2 USE OF ANTAGONISTS OF EGF OR TGF-ALPHA FOR THE TREATMENT AND PROPHYLAXIS OF ACNE UNILEVER PLC (GB) 1995-09-21 WO disclosed
EP-0580409-A2 Cosmetic composition containing DOPA derivatives UNILEVER PLC (GB) 1994-01-26 EP disclosed
EP-0572167-A1 Cosmestic composition UNILEVER PLC (GB) 1993-12-01 EP disclosed
EP-0571198-A1 Cosmetic composition containing hair-growth promoter UNILEVER PLC (GB) 1993-11-24 EP disclosed
EP-0517371-A2 Hair growth composition containing citric acid esters UNILEVER PLC (GB) 1992-12-09 EP disclosed
US-5124354-A Hair growth CHESEBROUGH POND'S USA CO., DIVISION OF CONOPCO, INC. (US) 1992-06-23 US disclosed
EP-0490581-A1 Cosmetic composition UNILEVER PLC (GB) 1992-06-17 EP disclosed