Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.68 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.68 |
| ▸ | MEN1 | O00255 | 6/20 | 0.68 |
| ▸ | HPGD | P15428 | 5/20 | 0.68 |
| ▸ | RECQL | P46063 | 4/20 | 0.68 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.68 |
| ▸ | BLM | P54132 | 3/20 | 0.68 |
| ▸ | LMNA | P02545 | 3/20 | 0.68 |
| ▸ | RGS12 | O14924 | 2/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.68 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.68 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.68 |
| ▸ | TSHR | P16473 | 2/20 | 0.68 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.68 |
| ▸ | APEX1 | P27695 | 2/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6278934 | 1.00 | MAPT (0.68) | MAPTALDH1A1KMT2ATDP1KDM4E | |
| Tyrphostin Ag 879 SCHEMBL607701 | 0.81 | MAPT (1.00) | MAPTALDH1A1KMT2ATDP1KDM4E | |
| Tyrphostin Ag 879 SCHEMBL607703 | 0.81 | MAPT (1.00) | MAPTALDH1A1KMT2ATDP1KDM4E | |
| Tyrphostin Ag 879 SCHEMBL607702 | 0.81 | MAPT (1.00) | MAPTALDH1A1KMT2ATDP1KDM4E | |
| SCHEMBL9487398 | 0.80 | RPS6KA3 (0.53) | ALDH1A1KDM4EHPGDCYP3A4EGFR | |
| SCHEMBL27993190 | 0.76 | MAPT (0.66) | MAPTALDH1A1KMT2ATDP1KDM4E | |
| SCHEMBL4561162 | 0.73 | EGFR (0.74) | MAPTALDH1A1KMT2ATDP1KDM4E | |
| SCHEMBL4561164 | 0.73 | EGFR (0.74) | MAPTALDH1A1KMT2ATDP1KDM4E | |
| SCHEMBL4561165 | 0.73 | EGFR (0.74) | MAPTALDH1A1KMT2ATDP1KDM4E | |
| SCHEMBL4878079 | 0.72 | MAPT (0.70) | MAPTALDH1A1KMT2ATDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE38761-E1 | Styryl compounds which inhibit EGF receptor protein tyrosine kinase | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 2005-07-19 | — | — | US | claimed |
| US-5217999-A | Antigrowth agents | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 1993-06-08 | — | — | US | claimed |