Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | AHR | P35869 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
| ▸ | PI4KA | P42356 | 1/20 | 0.35 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.35 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.35 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10492092 | 1.00 | SMN1; SMN2 (0.45) | SMN1; SMN2L3MBTL1MAPK1ALDH1A1KDM4E | |
| SCHEMBL24608559 | 0.80 | SMN1; SMN2 (0.48) | SMN1; SMN2L3MBTL1MAPK1ALDH1A1KDM4E | |
| SCHEMBL1921572 | 0.77 | SMN1; SMN2 (0.54) | SMN1; SMN2L3MBTL1MAPK1ALDH1A1KDM4E | |
| SCHEMBL29435883 | 0.77 | SMN1; SMN2 (0.54) | SMN1; SMN2L3MBTL1MAPK1ALDH1A1KDM4E | |
| SCHEMBL1114414 | 0.77 | SMN1; SMN2 (0.54) | SMN1; SMN2L3MBTL1MAPK1ALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL15353020 | 0.75 | SMN1; SMN2 (0.52) | SMN1; SMN2L3MBTL1MAPK1ALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL21810899 | 0.75 | SMN1; SMN2 (0.52) | SMN1; SMN2L3MBTL1MAPK1KDM4EAHR | |
| Ammonia Solution, Strong SCHEMBL2082802 | 0.75 | SMN1; SMN2 (0.52) | SMN1; SMN2L3MBTL1MAPK1ALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL19814625 | 0.75 | SMN1; SMN2 (0.52) | SMN1; SMN2L3MBTL1MAPK1KDM4EAHR | |
| SCHEMBL16296452 | 0.75 | MAPK1 (0.45) | SMN1; SMN2L3MBTL1MAPK1ALDH1A1AHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6887890-B2 | Compounds exhibiting thrombopoietin-like activities | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2005-05-03 | — | — | US | disclosed |
| US-20030162724-A1 | Compounds exhibiting thrombopoietin-like activities | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2003-08-28 | — | — | US | disclosed |
| EP-1291341-A1 | COMPOUNDS EXHIBITING THROMBOPOIETIN-LIKE ACTIVITIES | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2003-03-12 | — | — | EP | disclosed |
| US-4839465-A | SUBSTANCE P ANTAGONIST, HYPOTENSIVE AGENT, ANALGESICS | STERLING DRUG INC. (US) | 1989-06-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030162724-A1 | Compounds exhibiting thrombopoietin-like activities | MPL, THPO, TEK | SMN1; SMN2 1648/4885L3MBTL1 1806/4885MAPK1 338/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.